Hemianopsia, Homonymous Hemianopia, Tunnel Vision, Visual Field Constriction Bilateral, Visual Field Defect Homonymous Bilateral, Visual Field Defect, Peripheral
Conditions
Keywords
walking, collision, field expansion, visual field loss
Brief summary
The investigators are developing a new test of pedestrian hazard detection in virtual reality (VR) head-mounted display (HMD) headset, which shows virtual oncoming pedestrians in 3D while subjects are walking in real-world environment, for evaluation of visual field expansion to improve mobility in people with visual field loss.
Detailed description
The investigators will develop a new pedestrian hazard detection test and conduct a single arm interventional clinical trial to evaluate simulated low vision assistive devices in a sample of field loss subjects. Pedestrian detection performance with and without field expansion information will be tested and compared. The study will include 1 to 4 visits (each 2 to 4 hours) depending on the number of trials and experimental conditions (e.g., with and without simulated assistive devices) the subject is comfortable completing. The time between visits may vary depending on scheduling constraints and availability. During each visit, the subject will complete a series of simulated collision avoidance trials in VR requiring the detection and natural avoidance of a colliding pedestrian (alongside non-colliding pedestrians) while physically walking through an empty corridor. The study will be considered minimal-risk since there will be no physical obstacles that present actual collision risks.
Interventions
OTHERField expansion view
Overlaid small window on HMD to show the part of the scene in the blind field into portions of the participants' remaining, seeing, field of vision
Sponsors
Massachusetts Eye and Ear Infirmary
National Eye Institute (NEI)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
14 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* At least 14 years of age (no upper age limit) * In sufficiently good health to be able to complete sessions lasting 2-3 hours * Able to understand English * Able to give voluntary, informed consent * Able to independently move short distances * Binocular vision parameters within normal limits (Stereopsis ≤ 100 arc sec on any stereo test) * Visual field loss, either peripheral field loss (\<30 degrees diameter) or hemianopic field loss (blind in half of visual field) * Better than 20/100 visual acuity in the worse eye
Exclusion criteria
* Patients with any self-reported physical or mental disabilities, including cognitive dysfunction, balance problems, or other deficits that could impair their ability to respond to the stimuli presented in this study * Any person with a self-reported medical history (such as pacemaker use or photosensitive epilepsy) or physical condition listed on the device manual of the Oculus / HMD system used for the experiment as a contraindication * Any self-reported history of seizures (any type) in the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Response time | Through study completion, an average of four months | During the pedestrian detection task, average response time to the colliding pedestrian with and without prisms |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Head movement range | Through study completion, an average of four months | During the pedestrian detection task, lateral and vertical head movement range to check the head scanning range |
| Walking speed | Through study completion, an average of four months | During the pedestrian detection task, the physical walking speed of the subject |
| Pedestrian detection rate | Through study completion, an average of four months | Proportion of simulated pedestrians detected (in HMD walking) |
| Error rate | Through study completion, an average of four months | Proportion of false alarms and missed targets to total targets |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATOREli Peli, OD, MSc
Senior Scientist
Outcome results
None listed