Cognitive Dysfunction, Neuroimaging, Posterior Reversible Encephalopathy Syndrome
Conditions
Brief summary
The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
Detailed description
This is a prospective study. The investigators divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . The general information（demographic data，blood pressure.etc.）and blood sample will be collected. Additionally,all patients receive neuroimaging examination（DTI,ASL,3D-TMI.etc.）and neuro-cognitive test（MMSE,MOCA,CFQ, etc.） to assess the cerebral white matter lesions and cognitive changes.
Interventions
BIOLOGICALneuroimaging examination,neuro-cognitive test,blood pressure,blood sample
neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested
Sponsors
Dunjin Chen
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
15 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. patients were diagnosed of PE or E 2. patients received cranial image examination 3. patients consent to participate
Exclusion criteria
1. patients combined other neurological diseases 2. patients combined mental illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of LDL in blood | within 10 years after deliver | hyperlipidemia：LDL\>3.12mmol/L |
| neuroimaging examination | within 10 years after deliver | the degree of white matter lesions(0,normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema \> cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema \> cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost completely confluent; 5, involved regions are fully confluent and continuous, ventricular deformity due to the oedema).The value of fractional anisotropy(FA) in PRES group may higher than non- PRES group, and mean diffusivity (MD) in PRES group may lower than non- PRES group. |
| neuro-cognitive test of Mini-mental State Examination | within 10 years after deliver | the scores of Mini-mental State Examination,normal (27-30);mild (21-26); moderate (10-20); severe (0-9). |
| neuro-cognitive test of Montreal Cognitive Assessment | within 10 years after deliver | the scores of Montreal Cognitive Assessment,normal (≥26); abnormal (\<26). |
| blood pressure and hypertension | within 10 years after deliver | Hypertension: blood pressure ≥140/90 mmHg |
| level of lactate dehydrogenase(LDH) | within 10 years after deliver | inflammatory: LDH\>380U/L |
Countries
China
Contacts
Primary ContactDunjin Chen
Outcome results
None listed