Positron-Emission Tomography
Conditions
Keywords
Lymphatic System Related Diseases
Brief summary
To evaluate the potential usefulness of 68Ga-NOTA Evans Blue (68Ga-NEB) positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and efficacy assessment in lymphatic system related diseases.
Detailed description
Subjects with lymphatic system related diseases underwent 68Ga-NEB PET/CT either for a primary diagnosis or for efficacy assessment. Anomalies were detected by visual analysis and quantitative analysis of maximum standard uptake value (SUVmax). To compare the diagnostic sensitivity of 68Ga-NEB PET/CT lymphatic imaging with other lymphatic imaging such as 99mTc-dextran for lymphatic system related diseases.
Interventions
DRUG68Ga-NOTA Evans Blue
Each subject receives a single subcutaneous injection of 68Ga-NOTA Evans Blue, and undergo PET/CT imaging within the specific time.
Sponsors
First Affiliated Hospital of Fujian Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* adult population (aged between18 years and 80 years) * patients with suspected or new diagnosed or previously treated lymphatic system related diseases * patients who had scheduled 68Ga-NEB PET/CT scan * patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee
Exclusion criteria
* patients with pregnancy * the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual analysis of lymphatic patency | through study completion, an average of 3 years | The bilateral lymphatic description on 68Ga-NEB PET/CT and lymphatic SPECT imaging were compared. The patency of lymphatic vessels (including lymphatic disruption, dermal distribution, and so on, results are indicated by 0 and 1) are shown in two imagings were recorded respectively. |
| Standardized uptake value (SUV) | through study completion, an average of 3 years | Standardized uptake value (SUV) of 68Ga-NEB for each target lesion of subject. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic efficacy | through study completion, an average of 3 years | The sensitivity of 68Ga-NEB PET/CT and lymphatic SPECT imaging were calculated. |
Countries
China
Contacts
Primary ContactWeibing Miao, MD
Backup ContactMeiyan Lin, MD
Outcome results
None listed