Coagulation Disorder, Endocarditis, Valve Disease, Heart
Conditions
Brief summary
The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.
Detailed description
The aim of this study is to examine the differences between patients with and without endocarditis who undergo cardiothoracic (valve) surgery. In addition, the investigators will look at the differences between endocarditis patients who undergo surgery, and those who are treated conservatively. The investigators will look at incidence and degree of perioperative coagulation abnormalities, as well as transfusion and coagulation factor requirements, heparin resistance, bleeding scores, predictive endocarditis mortality scores, vasopressor-inotrope scores, and relate these where possible to the pathogen causing IE. The investigators will also look at perioperative complications, in particular, thromboembolic events and mortality at 30 and 90 days, and at 1 year. These outcomes may help optimise perioperative care for high-risk endocarditis patients, and in particular those undergoing valve surgery.
Interventions
OTHERNone, observational
Patients with infective endocarditis who do and do not undergo valve surgery compared with patientswithout endocarditis, who are operated on with similar valve surgery
Sponsors
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \> 18 years * Dutch or English speaking * All patients with infective endocarditis admitted to Amsterdam UMC in the study period * All patients with infective endocarditis scheduled for cardiac valve surgery compared to a matched cohort of patients scheduled for similar surgery due to non-infectious indication in Amsterdam UMC in the same period
Exclusion criteria
* Previous history of coagulation disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thromboembolic complications | up to 1 year | Any thromboembolic complications occuring between surgery and 1 year post operatively (incidence, class and severity) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of perioperative coagulation abnormalities | First 24 hours after surgery | How often perioperative coagulation abnormalities, measured by classical laboratory values and rotational thromboelastometry are seen from diagnosis to 24 hours post-surgery |
| Differences in incidence of pathogens and the relation with disease severity | Up to 30 days | To evaluate the effect of different pathogens (evaluated by laboratory results) on the clinical status |
Countries
Netherlands
Contacts
Primary ContactJennifer S Breel, MPA,MSc
Backup ContactHenning Hermanns, MD,PhD
Outcome results
None listed