Obesity, Weight Loss
Conditions
Keywords
resting metabolic rate, metabolic adaptation
Brief summary
This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.
Interventions
OTHERlifestyle intervention with meal replacement program
participants will be enrolled in a medical weight loss program and will be given a 6 month subscription to a calorie-reduced meal replacement program, in addition to lifestyle advice.
Sponsors
Medical College of Wisconsin
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
BMI \> or = 30 any ethnicity
Exclusion criteria
weight \> or = 400 lbs. diabetes (type 2 or type 1) hypertension heart disease kidney disease liver disease active cancer post solid organ or bone marrow transplant HIV/AIDS pregnancy breastfeeding current smoker current recreational drug use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in measured and predicted resting metabolic rate during and after weight loss | 18 months | resting metabolic rate will be measured by indirect calorimetry every 2 months for 6 months, then every 6 months for an additional 12 month. Predicted resting metabolic rate will be calculated with a mathematical formula at the same time points |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in circulating leptin during and after weight loss | 18 months | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
| change in circulating thyroid hormones during and after weight loss | 18 months | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
| change in circulating GLP-1 during and after weight loss | 18 months | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
| change in circulating PYY during and after weight loss | 18 months | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
| change in circulating AgRP during and after weight loss | 18 months | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
| change in 24h urine catecholamines during and after weight loss | 18 months | urine will be assayed for these hormones every 2 months for 6 months, then every 6 months for an additional 12 months |
| change in heart rate variability during and after weight loss | 18 months | blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORLisa L Morselli, MD PhD
Medical College of Wisconsin
Outcome results
None listed