Nutrition, Healthy
Conditions
Keywords
plant-based protein, whey protein, protein quality, muscle protein synthesis
Brief summary
The present investigation aims to study a novel plant based protein isolate blend to determine if it results in similar muscle building responses compared to whey protein isolate.
Detailed description
Whey protein is considered the 'gold standard' to maintain body proteins (muscle, skin, bone). When isolated from milk, whey protein isolate (WPI) contains all nine essential amino acids (EAA) which are 'building blocks' that are needed to support the maintenance of body proteins. To date, there is no plant-based protein (PBP) isolate that compares to the recommended WPI towards how our body builds or supports our muscles. WPI is considered the 'gold standard' because it contains all of the EAA which provide the right amount of 'building blocks' to support our muscles. Current PBP isolates available contain insufficient amounts of EAA, and are less digestible, resulting in less 'building blocks' available to support our muscles. Recently, plant protein combinations have been designed to provide the right amounts of all the EAAs. Therefore, the aim of the present study is to determine the effects of a novel PBP blend on muscle protein synthesis responses by comparing it to WPI.
Interventions
DIETARY_SUPPLEMENTProtein quality
the present investigation aims to study a novel protein based protein isolate blend with and without leucine an compared with whey protein isolate to determine its impact aminoacidemia and muscle protein synthesis healthy adults.
Sponsors
McMaster University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
The study design will be a randomized, double blind, crossover trial.
Intervention model description
The study design will be a randomized, double blind, crossover trial.
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
1. Male or female, between the ages of 18 - 30 years (inclusive) 2. Have a body mass index (BMI) between 18-30 kg·m2 (inclusive) 3. Be in general good health as assessed by a general health questionnaire 4. Non-smoking 5. Regular menstrual cycle and not using hormonal contraceptives 6. Willing and able to provide informed consent
Exclusion criteria
1. Currently using analgesic or anti-inflammatory drugs 2. A history of neuromuscular problems or muscle and/or bone wasting diseases 3. Any acute or chronic illness, metabolic disorders 4. Currently using corticosteroids 5. Use of hormonal contraceptives or anabolic steroids (e.g. testosterone)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle protein synthesis | Over a 5 hour period | A marker of muscle growth |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Aminoacidemia | Over a 5 hour period | Amino acids in the blood |
| Appetite and desire for specific food types in response to test drinks types H | Immediately before, and 30, 60, 120, 180 and 300 minutes after test drinks are consumed. | Questionnaire on appetite and palpability of the drinks assessed by a visual analogue scale. 100 mm in length with words anchored at each end, expressing the most positive and the most negative rating used to assess hunger, satiety and fullness. Higher scores mean a better outcome. |
| Palatability of test drinks | Immediately after test drink are consumed. | Questionnaire of palatability of test drinks assessed by a visual analogue scale. 100 mm in length with words anchored at each end, expressing the most positive and the most negative rating used to assess visual appeal, smell, taste, aftertaste and palatability. Higher scores mean a better outcome. |
| Questionnaire on safety | Over a 5 hour period | Safety will be measured via a questionnaire; e.g. can the participant drink the test drinks and are they okay? Yes or no. |
| Tolerability of test drinks | Over a 5 hour period | Tolerability will be measured using Visual Analog Scales anchored by the following descriptors: 0 - no symptoms at all; 100 - worst symptoms participant has ever experienced for the following: nausea, belching, feeling of fullness, vomiting, abdominal distension, flatulence, diarrhoea, dry mouth, and thirst. |
Countries
Canada
Outcome results
None listed