Peri-Implantitis
Conditions
Keywords
Er: YSGG laser therapy, Peri-Implantitis
Brief summary
This study will be carried out to evaluate the efficacy of Er: YSGG laser on oral biofilm removal from implant surface in various peri-implant defect morphology in the treatment of peri-implantitis as a primary objective. To assess the morphological changes and the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through Profilometer analysis and cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) respectively as secondary objectives.
Detailed description
This study will be carried out to evaluate the efficacy of Er: YSGG laser on oral biofilm removal from implant surface in various peri-implant defect morphology in the treatment of peri-implantitis as a primary objective. To assess the morphological changes and the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through Profilometer analysis and cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) respectively as secondary objectives. The study was designed as an Ex Vivo study. Four periodontally and systemically healthy volunteers of both gender are included in this study for the formation of in vivo plaque biofilm. Each volunteer will wear a hard resin splint carrying six rough (machined implant; 3.3mm diameter, 8mm length) for 4 days to accumulate dental plaque naturally on the titanium surfaces of the implants. Therefore, 24 implants will be assessed for Er: YSGG laser therapy in different bone defect simulators.
Interventions
DEVICEEr: YSGG laser
Er: YSGG laser decontamination of infected implant surfaces to simulate peri-implantitis therapy
OTHERno therapy
new sealed implant without any surface treatment
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Intervention model description
two group control and test group test group divided into four subgroups
Eligibility
Sex/Gender
ALL
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Sex: female or male. * Age: 25 - 55 years. * Medically controlled according to medical coding of review of systems (ROS)
Exclusion criteria
* Tobacco smoking for at least 6 months before the study enrollment * Participants with ill-fitting restorations in both upper first molars that affect the stability of the stent. * Participants not following oral hygiene instructions. * Participants on dental treatment during the study period. * Participants with a history of drug administration * Vulnerable group. * Participants with long-term mouthwash administration.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| visual inspection of the oral biofilm removal efficacy by image analysis software (Adobe Photoshop | 2 weeks | evaluate the efficacy of Er: YSGG laser on oral biofilm removal from implant surface in various peri-implant defect morphology |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Profilometer analysis of surface roughness changes | 1 month | assess the morphological changes of implant surface after Er: YSGG laser therapy through Profilometer analysis |
Other
| Measure | Time frame | Description |
|---|---|---|
| biocompatibility test of the surface | 2 months | assess the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) |
Countries
Egypt
Outcome results
None listed