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Cognitive Impairment and Upper Extremity Performance in COPD

Comparison of Upper Extremity Functional Capacity, Respiratory Functions, Fatigue and Quality of Life in Chronic Obstructive Pulmonary Patients With and Without Cognitive Impairment

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05137483
Acronym
COPD
Enrollment
80
Registered
2021-11-30
Start date
2021-11-19
Completion date
2022-07-30
Last updated
2021-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Upper Extremity, Upper Limb Function, Cognitive Impairment

Keywords

copd, cognitive impairment, cognition, upper extremity

Brief summary

Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction. Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the groups.

Detailed description

Although the mechanism of cognitive dysfunction in COPD is not clear, the reasons focused on are; decreased oxygen use, high carbon dioxide levels, increased inflammation and oxidative stress, decreased physical activity, peripheral vascular diseases, atherosclerosis, high or low blood pressure, cerebral vasoconstriction, increased intracranial pressure, accompanying comorbidities, smoking and genetic predisposition, brain damage and exacerbations have been reported. Few studies have shown that cognitive dysfunction is associated with functional performance. There are no studies on the effect of cognitive function on upper extremity performance and mechanisms of action in COPD patients. The aim of this study is to compare upper extremity functional capacities, respiratory functions, fatigue and quality of life in COPD patients with and without cognitive function impairment. Within the scope of this study, COPD patients will be divided into two groups according to cognitive dysfunction. Pulmonary function test, COPD assessment scale, Mini-Mental State Examination and Montreal Cognitive Assessment Scale, 6 min pegboard ring test, grip strength measurement, Fatigue Impact Scale and St.George Respiratory Questionnaire will be applied to the groups.

Interventions

We will apply upper extremity performance tests, hand grip measurements, and scales measuring fatigue and quality of life to the groups.

Sponsors

Izmir Katip Celebi University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
45 Years to No maximum

Inclusion criteria

* Volunteering to participate in the study * Stage 2-3-4 according to the GOLD classification in the 40-65 age range

Exclusion criteria

* Exacerbation of respiratory symptoms in the past 4 weeks (change in breathlessness and/or sputum volume/color, need for antibiotic treatment or need for hospitalization) * Presence of asthma, unstable coronary heart disease, uncontrolled diabetes, hypertension, left-sided congestive heart failure, neoplasia, severe claudication, encephalitis or epilepsy * Having a history of head trauma or brain tumor * Having a significant psychiatric condition or the presence of defined dementia, according to the American Psychiatric Association

Design outcomes

Primary

MeasureTime frameDescription
6 min. pegboard ring test6 minutesIt is used to measure upper extremity functional capacity.

Secondary

MeasureTime frameDescription
Mini Mental State Test15 minutesIt is used for measuring cognitive impairment
Montreal Cognitive Assessment Scale30 minutesIt is used for measuring cognitive impairment
Fatigue Impact ScaleTime Frame: 20 minutesIt is used for measuring fatigue level
Respiratory Function Test20 minutesIt is used for measuring lung functions and respiratory muscle strength
COPD Assessment Test10 minutesIt is used for measuring health status of COPD patients
mMRC Dyspnea Scale5 minutesIt is used for measuring dyspnea sensation in daily living activities
St. George Respiratory Questionnaire20 minutesIt is used for measuring desase-related quality of life

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026