Perineal Surgery
Conditions
Brief summary
To compare between intrathecal atropine versus preoperative administration of IV ondansetron in decreasing incidence of post operative nausea and vomiting related to intrathecal opioids in post operative period in perineal surgery as regard : efficacy and side effects .
Interventions
DRUGOndansetron , atropine and bupivacaine
Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% ) with morphine 250mic and atropine sulphate 100 micwith total volume = 2.5 ml . Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% with 0.5 ml normal saline with morphine 250 mic ) with total volume = 2.5 ml with giving 4 mg IV ondansetron before anesthesia ( patients with body weight more than 80 Kg may need additional 4 mg IV ) .
Sponsors
Sohag University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between ( 18 - 45 ) years. * Body mass index between ( 18.5 - 35 ) * patients undergoing perineal surgery as anal fissure , piles and rectocele * patients receiving bupivacaine ( 20 mg / 4 ml ) as spinal anesthesia * Patinets with physical status 1 or 2 according to ASA classification
Exclusion criteria
* Patient refusal . * Any contraindication of neuraxial block as : coagulopathy , skin infection at injection site or bacteremia , hypovolemia and shock , history of allergy to L.A , sever aortic stenosis or mitral stenosis ……… etc * Patients with physical status other than 1 and 2 according to ASA classification * Those with history of nausea and vomiting , also those who received anti emetic drugs in last 2 hours of operation . * Allergy to any of the drug included in this study .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| frequency of attacks of postoperative nausea and vomiting | 6-9 months | Intrathecal atropine versus preoperative intravenous ondasetron for prevention of postoperative nausea and vomiting due to intrathecal morphine |
Countries
Egypt
Contacts
Primary Contactshehab m mohamed, resident
Backup Contactelhadad a mousa, professor
Outcome results
None listed