Heart Valve Surgery
Conditions
Keywords
Gut Microbiota, polysomnography
Brief summary
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass.
Detailed description
The investigators designed a study to assess whether there is any change in gut microbiota and postoperative sleep before and after heart valve surgery with cardiopulmonary bypass. Firstly, this study aims to characterize the gut microbiota in patients with valve disease treated with surgery. Secondly, it aims to evaluate microbiota and its influence on postoperative sleep.
Interventions
DEVICEpolysomnography
Duration of sleep was collected with polysomnography on second postoperative night. (from 20:00pm to 06:00am).
Sponsors
China Medical University, China
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Ethnic Chinese; * Age, 18 to 65 years old; * Patients undergoing heart valve surgery with cardiopulmonary bypass
Exclusion criteria
* Preoperative Pittsburgh Sleep Quality Index global scores higher than 6 * Cognitive difficulties * Partial or complete gastrectomy * Previous esophageal surgery * Previous treated by radiotherapy or surgery * Inability to conform to the study's requirements * Body mass index exceeding 30 kg/m2 * Deprivation of a right to decide by an administrative or juridical entity * Ongoing participation or participation in another study \<1 month ago * Recent (\< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, laxatives, proton pump inhibitors, insulin sensitizers or traditional Chinese medicine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gut microbiota | from baseline to postoperative 72 hours | This study will characterize the gut microbiota in one group of 36 patients before and after heart valve surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative sleep | on the second postoperative night from 20:00 to 6:00 | This study will characterize the postoperative sleep measured by polysomnography in one group of 36 patients after heart valve surgery |
| serum metabolites | from baseline to postoperative 72 hours | This study will characterize the serum metabolites in one group of 36 patients before and after heart valve surgery |
Countries
China
Outcome results
None listed