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Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training

Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05135247
Enrollment
61
Registered
2021-11-26
Start date
2015-01-10
Completion date
2017-07-10
Last updated
2021-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autonomic Dysfunction

Keywords

older individuals, heart rate variability, physical training, hypertension

Brief summary

Sixty-one sedentary older hypertensive individuals were randomized to four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C) group. The protocol included 3 sessions of training by week for 12 weeks. C individuals were instructed to continue their usual activities. They were submitted to the passive tilt test before and after the research protocol, evaluating the heart rate (HR), low frequency (LF) and high frequency (HF) bands, detrended fluctuation analysis (DFAα1) and entropy

Detailed description

The individuals were randomized into four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C), which performed physical exercises three times a week for twelve weeks, with a total of 36 sessions. The tilt test was performed before and after the research protocol. Individuals in the control group were only encouraged to maintain their usual activities. For the analysis of HRV, the baseline conditions (resting in the supine position) were determined, followed by the passive postural maneuver, which characterizes the tilt test (table til tat 70 °) in order to determine the following variables: * HR: heart rate (sympathetic action) * LF: Low frequency band (Modulated predominantly by the sympathetic system) * HF: High frequency band (Modulated predominantly by the parasympathetic system) * Entropy: data complexity or irregularity index showing that, the higher the values, the better the HRV. * DFAα1 (short term detrended fluctuation analysis)

Interventions

OTHERExercise

3 different types of training or control

Sponsors

University of Sao Paulo
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

The individuals were randomized into four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C), which performed physical exercises three times a week for twelve weeks, with a total of 36 sessions. The tilt test was performed before and after the research protocol. Individuals in the control group were only encouraged to maintain their usual activities.

Eligibility

Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

men and women 60-year-old or older, extensively using prescription antihypertensive drugs, and having no previous experience with physical training -

Exclusion criteria

* • Positive treadmill test (TT) for ischemia * Related left ventricular systolic dysfunction of any degree * Presence of arrhythmias * Use of β-blockers * Use more than seven doses of ethyl alcohol per week * Renal insufficiency * Diabetes * Hyper- or hypothyroidism * Limiting lung disease * Osteomioarticular impairment that would limit exercise performance * SBP ≥160 and/or DBP ≥ 100 mmHg on baseline

Design outcomes

Primary

MeasureTime frameDescription
Heart rate12 weeksHeart rate was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.
Low frequency band12 weeksLow frequency band was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.
High frequency band12 weeksHigh frequency band was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.
Entropy12 weeksEntropy was obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.
Short term detrended fluctuation analysis12 weeksShort term detrended fluctuation analysis obtained before and after the protocol by electrocardiogram, performed before and after tilt test at each time.The electrical signal from the electrocardiogram was filtered and amplified. The amplified signals were processed by ananalog-digital converter (DI-720, DATAQ Instruments, Akron, OH, USA) and sampled (1000 hz per channel) by a computer program (Windaq, DATAQ, Akron, OH, USA) installed in an IBM/PC computer.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026