Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment

Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment: Functional Protection of the Lung and Prevention of Radiation Pneumonitis

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05134558

Enrollment

Registered

2021-11-26

Start date

2020-02-04

Completion date

2024-12-31

Last updated

2021-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Cancer, Radiation Therapy Complication

Keywords

lung cancer, Radiation Therapy, Xenon-enhanced ventilation CT

Brief summary

The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Detailed description

There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Interventions

RADIATIONXenon-enhanced Ventilation CT-guided Radiotherapy

Xenon-enhanced Ventilation CT-guided Radiotherapy for functional protection of the lung

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024.

Exclusion criteria

* The age is less than 20 years old or older than 80 years old. * Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon. * Renal insufficiency patients. * Claustrophobia * Those who are pregnant.

Design outcomes

Primary

Measure	Time frame	Description
Incidence of radiation pneumonia	Within 1 year of radiation therapy	Incidence of radiation pneumonia

Countries

Taiwan

Contacts

Primary ContactYu-Sen Huang, Md PhD

yusen0814@gmail.com+886-23123456

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026