Hypertension, Preeclampsia, Recurrence
Conditions
Brief summary
The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.
Detailed description
The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.
Interventions
OTHERblood pressure,BMI, blood sample
Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.
Sponsors
Dunjin Chen
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* women with at least twice of delivery history
Exclusion criteria
* women with chronic hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of AST and ALT in blood | 1year after the second deliver | women |
| blood pressure and hypertension of offspring | 1 year old | blood pressure≥140/90 mmHg |
| level of glycosylated hemoglobin in blood | 1 year after the second deliver | women |
| level of cholesterol, LDL, HDL, VLDL-C in blood | 1 year after the second deliver | women |
| level of FT3,FT4, and hTSH in blood | 1year after the second deliver | women |
| blood pressure and hypertension of women | 1year after the second deliver | blood pressure ≥140/90 mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| level of insulin in blood | 1year after the second deliver | women |
| level of fructosamine in blood | 1year after the second deliver | women |
| level of AI37℃、AI4℃、PRA、ALD、AngII in blood | 1 year after the second deliver | women |
| BMI of offspring | 1 year old | weight(kg)/height(m)2 |
Countries
China
Contacts
Primary ContactDunjin Chen
Outcome results
None listed