Acute Coronary Syndrome
Conditions
Brief summary
Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.
Detailed description
Prospective study to : 1. find the relation between electrolytes disturbance and renal diseases 2. the effect of electrolyte abnormalities on atherosclerosis 3. prevalence of acute coronary syndrome in patients with chronic kidney disease
Interventions
DIAGNOSTIC_TESTSerum Calcium
* Serum calcium level. * Serum phosphorus level. will be measured to all study population
Sponsors
Sohag University
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 1-The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : a- Electrocardiogram (ECG) changes: * ST elevation. * ST depression. * T wave inversion. * recent left bundle branch block. b- Troponin T elevation. 2-The CKD patient with or without dialysis with no previous history of ACS.
Exclusion criteria
1. Patients who were diagnosed with primary hyperparathyroidism. 2. Acute Kidney injury (AKI) which is defined as any of the following:(KDIGO2012) * Increase in S.Cr by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) within 48hours; or * Increase in S.Cr to ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days;or * Urine volume \<0.5 ml/kg/h for 6 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Chronic kidney disease hospitalization | from the day of admission to the day of discharge through study completion, an average of 28 weeks, in sohag university hospital | The CKD patient with and without acute coronary syndrome and estimated hazard ratios (HR) by use of multivariable Cox regression models. |
Countries
Egypt
Contacts
Primary ContactAhmed M YOUSEF, M.B.B.CH
Outcome results
None listed