Neurocognitive Disorders
Conditions
Keywords
Brain pulse, ultrasound
Brief summary
Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders. Patients are then usually followed up in consultation at least once a year, in the framework of a new day hospital and/or consultations with a MRRC doctor.
Detailed description
Patients will be included at the time of the day hospital assessment. All patients received in the day hospital of the MRRC of Tours will be offered the TPI examination. The patients included will be followed up for a period of 5 years and the TPI examination will be repeated according to the same modalities, as part of their follow-up at the MRRC and/or in the context of a new day hospital if necessary.
Interventions
OTHERUltrasound examination
Ultrasound examination with Tissue Pulsatility Imaging (TPI) TPI is a relatively simple, rapid and non-invasive ultrasound examination which consists of applying a standard ultrasound probe to the acoustic window of the temporal bone to first measure the velocity of the middle cerebral artery in Doppler mode and secondly the cerebral pulsatility (CP) of a region of approximately 10cm2 centred on the middle cerebral artery in B-Echo mode. After collecting the information, the TPI examination will be performed by MRRC staff specially trained in TPI by engineers. The duration of the examination is between 20 and 30 minutes, including hardware installation. Four 30-second PC acquisitions will be collected per examination, with the patient lying supine on the bed in the day hospital room, then one measurement every minute for 3 minutes after standing.
Sponsors
University Hospital, Tours
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions
Exclusion criteria
* Refusal of TPI ultrasound examination * Patients who opposed to data processing * Patients under judicial protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximum amplitude of brain movements | one a year from inclusion visit to 5 years | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). |
| mean of brain movements | one a year from inclusion visit to 5 years | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). |
| standard deviation of brain movements | one a year from inclusion visit to 5 years | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). |
| powers in frequency analysis | one a year from inclusion visit to 5 years | Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain pulse | one a year from inclusion visit to 5 years | Longitudinal comparison between converter patients (patients with mNCD progressing to MNCD) and non-converters patients |
| Hippocampal volume | one a year from inclusion visit to 5 years | Measured in MRI. Comparison with brain pulse according to Schelten classification |
| leucoaraiosis load | one a year from inclusion visit to 5 years | Measured in MRI. Comparison with brain pulse according to Fazekas classification |
| Carbohydrate metabolism | one a year from inclusion visit to 5 years | Measured with PET-FDG in regions of interest involved in neurodegenerative diseases. Comparison with brain pulse |
| Spinal fluid biomarkers | one a year from inclusion visit to 5 years | Determination of amyloid and tau proteins in spinal fluid. Comparison with brain pulse |
| cohort study on brain pulsatility with neuropsychological measures | one a year from inclusion visit to 5 years | Comparison between brain pulsatility parameters and standard neuropsychological test scores used for cognitive assessment of patients with NCD. neuropsychological test scores are optional at each visit |
Countries
France
Contacts
CONTACTThomas DESMIDT
CONTACTDominique BOMIA
PRINCIPAL_INVESTIGATORThomas DESMIDT
University Hospital, Tours
Outcome results
None listed