SARS-CoV2 Infection
Conditions
Keywords
SARS-CoV-2, Immune response, Children
Brief summary
The Coronavirus Pediatric Serological Study's aim is to provide a better insight of children's immune response after SARS-CoV-2 infection. Serological tests were conducted on blood samples taken 3 to 5 months after the children's viral infection. The study was performed in collaboration with the Institute of Medical Immunology, were antibody levels were measured and immunoglobulin subclasses profiles were studied.
Detailed description
The hospital laboratory provided us the list of children under 15 years old tested for SARS-CoV-2 in Saint-Pierre Hospital (Brussels) by PCR on nasopharyngeal swab between March 1 2020 and December 31 2020. The medical files of all children that were tested positive for SARS-CoV-2 were reviewed and clinical information was collected. For each positive child, the family was contacted by phone 3 months after the proven viral infection in order to ask permission to take a single blood test. Covid19 serologies were performed in the hospital laboratory, and blood samples were then sent to the Institute of Medical Immunology, were antibody levels and immunoglobulin subclasses were studied.
Interventions
DIAGNOSTIC_TESTBlood sample
Blood sample taken 3 to 5 months after the infection
Sponsors
Centre Hospitalier Universitaire Saint Pierre
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Months to 179 Months
Healthy volunteers
Yes
Inclusion criteria
\- Tested positive for SARS-CoV-2 by PCR on naso-pharyngeal swab performed in Saint-Pierre Hospital (Brussels) between March 1 2020 and December 31 2020
Exclusion criteria
* /
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SARS-CoV-2 antibody levels in asymptomatic patients | 3 to 5 months after SARS-CoV-2 infection | Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who did not show any symptoms at the time of the viral infection |
| SARS-CoV-2 antibody levels in mildly symptomatic patients | 3 to 5 months after SARS-CoV-2 infection | Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children presenting mild symptoms at the time of the viral infection |
| SARS-CoV-2 antibody levels in hospitalized patients | 3 to 5 months after SARS-CoV-2 infection | Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who required an hospitalisation at the time of the viral infection |
Countries
Belgium
Outcome results
None listed