Breast Cancer
Conditions
Brief summary
This is a retrospective propensity score-matched analysis of a large institutional cohort of patients in order to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery or mastectomy for breast cancer.
Detailed description
The aim of the study is to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery + whole breast irradiation or mastectomy for breast cancer. Recent observations regarding long-term outcomes among patients with early-stage breast cancer who underwent breast-conserving surgery plus whole-breast irradiation or mastectomy are from a small number of registry-based studies. Therefore, these findings may overestimate differences in survival between the two groups, compared with randomized controlled trials conducted in the 1980s. This study performed a propensity score-matched analysis in a cohort of 9710 patients aged \<70 years who underwent breast conserving surgery + whole breast irradiation or mastectomy without external radiotherapy for a first primary breast cancer (pT1-2, N0-3a) at the European Institute of Oncology between 2000 and 2008. Patients were matched by propensity score.
Interventions
PROCEDUREBreast-conserving surgery
Breast conserving surgery plus whole breast irradiation
PROCEDUREMastectomy
Breast mastectomy
Sponsors
European Institute of Oncology
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* First primary breast cancer * pT1-2 * pN0-3a * Surgery performed at European Institute of Oncology between 2000 and 2008
Exclusion criteria
* pT\>=3 * Neoadjuvant treatment * Presence of metastatic breast disease at the time of admission or within 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative incidence of ipsilateral breast tumor recurrence | 10 years | Incidence of ipsilateral breast tumor recurrence in breast conserving surgery group compared to mastectomy group |
| Cumulative incidence of axillary lymph node recurrence | 10 years | cumulative incidence of axillary lymph node recurrence in breast conserving surgery group compared to mastectomy group |
| Cumulative incidence of contralateral breast cancer | 10 years | Cumulative incidence of contralateral breast cancer in breast conserving surgery group compared to mastectomy group |
| Rate of distant metastasis | 10 years | Incidence of distant metastasis in breast conserving surgery group compared to mastectomy group |
| Cumulative incidence of breast cancer specific survival | 10 years | Cumulative incidence of breast cancer specific survival in breast conserving surgery group compared to mastectomy group |
| Rate of overall survival | 10 years | Incidence of survival in breast conserving surgery group compared to mastectomy group |
Outcome results
None listed