Efficacy of Chronoterapy in Oral Surgery

Efficacy of the Dosage of a Non-steroidal Anti-inflammatory (Ibuprofen) on Inflammation and Postoperative Pain After Lower Third Molar Surgery.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05126264

Acronym

ECOS

Enrollment

Registered

2021-11-18

Start date

2021-12-10

Completion date

2022-02-02

Last updated

2022-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Response, Pain, Tooth, Impacted, Trismus

Keywords

Third molar, Chronotherapy, Ibuprofen, Randomized

Brief summary

Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration. The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (ibuprofen) affects on postoperative pain, swelling and open mouth limitation comparing to the normal dosage.

Detailed description

A randomized crossover split-mouth clinical trial will be performed. After third molar extractions, patients will be prescribed ramdomly in one side wit the normal medication dosage while the contralateral side will be prescribed a modified dosage. Moreover, a blood sample will be obtained to analize the inflammatory profile.

Interventions

DRUGIbuprofen 400 mg

morning and afternoon

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Intervention model description

Split-mouth design

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Age between 18 and 35 years old * Bilateral retained lower third molar

Exclusion criteria

* NSAID allergic * Contraindication for surgical removal of third molar

Design outcomes

Primary

Measure	Time frame	Description
Post operative Pain	From the day of the surgical procedure to the seventh-day	Postoperative pain with visual analogue scale (VAS) from 0 (no pain) to 10 (maximum pain)

Secondary

Measure	Time frame	Description
Swelling	Baseline and post operatory (day 1, day 3, day 7)	Distance from tragus to pogonion in milimiters

Other

Measure	Time frame	Description
Trismus	Baseline and post operatory (day 1, day 3 and day 7)	Open mouth limitation in milimiters. Interincisal distance

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026