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Buddhist Understanding and Reduction of Myanmar Experiences of HIV Stigma and Exclusion

Buddhist Understanding and Reduction of Myanmar Experiences of HIV Stigma and Exclusion

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05126225
Acronym
BURMESE
Enrollment
19
Registered
2021-11-18
Start date
2020-07-01
Completion date
2024-04-30
Last updated
2025-12-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hiv, Mindfulness, Stigma, Social

Keywords

stigma, Mindfulness, Myanmar

Brief summary

This project aims to explore a multi-leveled conceptualization of the effects of HIV stigma on HIV care engagement in Myanmar by conducting a mixed-method study.

Detailed description

This project is to explore how Myanmar People Living With HIV (PLWH) experience and manage HIV stigma as inspired by Buddhist teaching, and to adapt an evidence-based stigma-reduction intervention to tailor treatment for the unique needs of Myanmar People Living With HIV. A stigma-reduction intervention will be adopted to the needs of Myanmar People Living With HIV with six focus groups.

Interventions

The intervention is modularized to have eight weekly sessions of 2-hour group discussions, led by a trained facilitator. The facilitator applies the principle of CBT and provides psychoeducation to promote the awareness and understanding of HIV stigma as well as training to help participants acquire alternative coping skills, such as relaxation techniques.

Sponsors

Chiangmai Rajabhat University
CollaboratorUNKNOWN
Fogarty International Center of the National Institute of Health
CollaboratorNIH
University of California, Los Angeles
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Intervention model description

The intervention is modularized to have eight weekly sessions of 2-hour group discussions, led by a trained facilitator.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. HIV-Positive 2. Care by Myanmar Positive Group/CMRU 3. Living in Myanmar/Thailand 4. can stay in the period of intervention

Exclusion criteria

1. Not HIV 2. Living outside of Myanmar/Thailand 3. Not care by MPG/CMRU 4. Cannot stay for the study period

Design outcomes

Primary

MeasureTime frameDescription
Change in Stigma Score From Baseline to End of Intervention in Protocol GroupBaseline and 8 weeksPerceived Stigma Scale (PSS). Each item is measured using a 4-point Likert scale and the scale contains four factors: personalized stigma (18 items, subscore total 18-72), disclosure concerns (12 items, subscore total 12-48), negative self-image (9 items, subscore total 9-36), and concern with public attitudes about people with HIV (12 items, subscore total 12-48). Each factor is scored separately, with total score is computed by summing all 40 items, with a minimum total PSS score of 40 and a maximum possible score of 160. Raw PSS scores were transformed into Stigma scores 1-4. Higher scores reflect higher levels of perceived stigma.

Secondary

MeasureTime frameDescription
Change in QOL Score From Baseline to End of Intervention in the Protocol GroupBaseline and 8 weeksCognitive and Affective Mindfulness Scale-Revised (CAMS-R) is a 12-item questionnaire that was used as a proxy measure of QOL in the study. Total maximum score of CAMS-R is 48 and minimum score is 12. Raw CAMS-R scores were transformed into QOL scores 0-3. Higher scores reflect better QOL.

Countries

Burma, Thailand

Participant flow

Pre-assignment details

The mixed methods study included interviews (n=32), focus groups (n=60) and a single arm interventional trial (n=19). The first part of the study consisted of interviews and focus groups from different stakeholders (PLWH, healthcare providers, family members, friends, etc.) which gathered data that was used to inform the intervention; outcomes were not collected from these participants. The second part of the study implemented the intervention in a single-arm pilot study with PLWH participants.

Participants by arm

ArmCount
Protocol Group
The protocol group was comprised of the participants who received the final, adapted study intervention over the course of 8 weeks. The intervention is modularized to eight weekly sessions of 2-hour group discussions. The facilitator applies the principle of Cognitive Behavior Therapy and provides psychoeducation to promote the awareness and understanding of HIV stigma as well as training to help participants acquire alternative coping skills, such as relaxation techniques. In five sessions, participants are introduced to the general cognitive-behavioral model of HIV stigma and are encouraged to track their thoughts, feelings, and behavioral responses when encountering external stigma or adverse events. The participants further learn to differentiate helpful and non-helpful coping strategies and practice applying helpful coping skills to effectively reduce their HIV stigma. In the other three sessions, participants further discuss more specific stigma that intersects with HIV stigma, including stigma in healthcare settings, access to social support, and available resources on the society levels. Stigma reduction: The intervention is modularized to have eight weekly sessions of 2-hour group discussions, led by a trained facilitator. The facilitator applies the principle of CBT and provides psychoeducation to promote the awareness and understanding of HIV stigma as well as training to help participants acquire alternative coping skills, such as relaxation techniques.
19
Interview Group
Interviews were conducted during the first phase of the study. With the goal of culturally adapting an existing intervention for use among people living with HIV from Myanmar, in-depth interviews were conducted with people living with HIV from Myanmar to explore and identify Buddhist conceptualizations of HIV stigma. Participants in the interview group were not followed for outcomes or AEs.
32
Focus Group
During the second step of the study, focus groups made up of Myanmar people living with HIV were presented the adapted intervention. Feasibility, acceptability, and appropriateness was assessed that informed the final version of the adapted study intervention for use in the target population. Participants in the focus group were not followed for outcomes or AEs.
60
Total111

Baseline characteristics

CharacteristicProtocol GroupInterview GroupFocus GroupTotal
Age, Continuous35.4 years39 years39 years37.8 years
Ethnicity (NIH/OMB)
Hispanic or Latino
0 Participants0 Participants0 Participants0 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
19 Participants32 Participants60 Participants111 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Asian
19 Participants32 Participants60 Participants111 Participants
Race (NIH/OMB)
Black or African American
0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
More than one race
0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
White
0 Participants0 Participants0 Participants0 Participants
Sex: Female, Male
Female
9 Participants20 Participants20 Participants49 Participants
Sex: Female, Male
Male
10 Participants12 Participants40 Participants62 Participants
Stigma score2.2358 score
STANDARD_DEVIATION 0.56062
2.2358 score
STANDARD_DEVIATION 0.56062

Adverse events

Event typeEG000
affected / at risk
deaths
Total, all-cause mortality
0 / 19
other
Total, other adverse events
0 / 19
serious
Total, serious adverse events
0 / 19

Outcome results

Primary

Change in Stigma Score From Baseline to End of Intervention in Protocol Group

Perceived Stigma Scale (PSS). Each item is measured using a 4-point Likert scale and the scale contains four factors: personalized stigma (18 items, subscore total 18-72), disclosure concerns (12 items, subscore total 12-48), negative self-image (9 items, subscore total 9-36), and concern with public attitudes about people with HIV (12 items, subscore total 12-48). Each factor is scored separately, with total score is computed by summing all 40 items, with a minimum total PSS score of 40 and a maximum possible score of 160. Raw PSS scores were transformed into Stigma scores 1-4. Higher scores reflect higher levels of perceived stigma.

Time frame: Baseline and 8 weeks

Population: Single-arm analysis was conducted in the protocol group.

ArmMeasureGroupValue (MEAN)Dispersion
Protocol groupChange in Stigma Score From Baseline to End of Intervention in Protocol GroupPre-test stigma score2.2358 scoreStandard Deviation 0.56062
Protocol groupChange in Stigma Score From Baseline to End of Intervention in Protocol GroupPost-test stigma score2.1760 scoreStandard Deviation 0.69976
p-value: 0.0595% CI: [0.032, 0.96]t-test, 2 sided
Secondary

Change in QOL Score From Baseline to End of Intervention in the Protocol Group

Cognitive and Affective Mindfulness Scale-Revised (CAMS-R) is a 12-item questionnaire that was used as a proxy measure of QOL in the study. Total maximum score of CAMS-R is 48 and minimum score is 12. Raw CAMS-R scores were transformed into QOL scores 0-3. Higher scores reflect better QOL.

Time frame: Baseline and 8 weeks

Population: Single-arm analysis was conducted in the protocol group.

ArmMeasureGroupValue (MEAN)Dispersion
Protocol groupChange in QOL Score From Baseline to End of Intervention in the Protocol GroupPre-test QOL score2.73 scoreStandard Deviation 0.82
Protocol groupChange in QOL Score From Baseline to End of Intervention in the Protocol GroupPost-test QOL score2.68 scoreStandard Deviation 0.9
p-value: 0.0595% CI: [0.16, 0.44]t-test, 2 sided

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026