Hiv, Mindfulness, Stigma, Social
Conditions
Keywords
stigma, Mindfulness, Myanmar
Brief summary
This project aims to explore a multi-leveled conceptualization of the effects of HIV stigma on HIV care engagement in Myanmar by conducting a mixed-method study.
Detailed description
This project is to explore how Myanmar People Living With HIV (PLWH) experience and manage HIV stigma as inspired by Buddhist teaching, and to adapt an evidence-based stigma-reduction intervention to tailor treatment for the unique needs of Myanmar People Living With HIV. A stigma-reduction intervention will be adopted to the needs of Myanmar People Living With HIV with six focus groups.
Interventions
The intervention is modularized to have eight weekly sessions of 2-hour group discussions, led by a trained facilitator. The facilitator applies the principle of CBT and provides psychoeducation to promote the awareness and understanding of HIV stigma as well as training to help participants acquire alternative coping skills, such as relaxation techniques.
Sponsors
Study design
Intervention model description
The intervention is modularized to have eight weekly sessions of 2-hour group discussions, led by a trained facilitator.
Eligibility
Inclusion criteria
1. HIV-Positive 2. Care by Myanmar Positive Group/CMRU 3. Living in Myanmar/Thailand 4. can stay in the period of intervention
Exclusion criteria
1. Not HIV 2. Living outside of Myanmar/Thailand 3. Not care by MPG/CMRU 4. Cannot stay for the study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Stigma Score From Baseline to End of Intervention in Protocol Group | Baseline and 8 weeks | Perceived Stigma Scale (PSS). Each item is measured using a 4-point Likert scale and the scale contains four factors: personalized stigma (18 items, subscore total 18-72), disclosure concerns (12 items, subscore total 12-48), negative self-image (9 items, subscore total 9-36), and concern with public attitudes about people with HIV (12 items, subscore total 12-48). Each factor is scored separately, with total score is computed by summing all 40 items, with a minimum total PSS score of 40 and a maximum possible score of 160. Raw PSS scores were transformed into Stigma scores 1-4. Higher scores reflect higher levels of perceived stigma. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in QOL Score From Baseline to End of Intervention in the Protocol Group | Baseline and 8 weeks | Cognitive and Affective Mindfulness Scale-Revised (CAMS-R) is a 12-item questionnaire that was used as a proxy measure of QOL in the study. Total maximum score of CAMS-R is 48 and minimum score is 12. Raw CAMS-R scores were transformed into QOL scores 0-3. Higher scores reflect better QOL. |
Countries
Burma, Thailand
Participant flow
Pre-assignment details
The mixed methods study included interviews (n=32), focus groups (n=60) and a single arm interventional trial (n=19). The first part of the study consisted of interviews and focus groups from different stakeholders (PLWH, healthcare providers, family members, friends, etc.) which gathered data that was used to inform the intervention; outcomes were not collected from these participants. The second part of the study implemented the intervention in a single-arm pilot study with PLWH participants.
Participants by arm
| Arm | Count |
|---|---|
| Protocol Group The protocol group was comprised of the participants who received the final, adapted study intervention over the course of 8 weeks.
The intervention is modularized to eight weekly sessions of 2-hour group discussions. The facilitator applies the principle of Cognitive Behavior Therapy and provides psychoeducation to promote the awareness and understanding of HIV stigma as well as training to help participants acquire alternative coping skills, such as relaxation techniques. In five sessions, participants are introduced to the general cognitive-behavioral model of HIV stigma and are encouraged to track their thoughts, feelings, and behavioral responses when encountering external stigma or adverse events. The participants further learn to differentiate helpful and non-helpful coping strategies and practice applying helpful coping skills to effectively reduce their HIV stigma. In the other three sessions, participants further discuss more specific stigma that intersects with HIV stigma, including stigma in healthcare settings, access to social support, and available resources on the society levels.
Stigma reduction: The intervention is modularized to have eight weekly sessions of 2-hour group discussions, led by a trained facilitator. The facilitator applies the principle of CBT and provides psychoeducation to promote the awareness and understanding of HIV stigma as well as training to help participants acquire alternative coping skills, such as relaxation techniques. | 19 |
| Interview Group Interviews were conducted during the first phase of the study. With the goal of culturally adapting an existing intervention for use among people living with HIV from Myanmar, in-depth interviews were conducted with people living with HIV from Myanmar to explore and identify Buddhist conceptualizations of HIV stigma. Participants in the interview group were not followed for outcomes or AEs. | 32 |
| Focus Group During the second step of the study, focus groups made up of Myanmar people living with HIV were presented the adapted intervention. Feasibility, acceptability, and appropriateness was assessed that informed the final version of the adapted study intervention for use in the target population. Participants in the focus group were not followed for outcomes or AEs. | 60 |
| Total | 111 |
Baseline characteristics
| Characteristic | Protocol Group | Interview Group | Focus Group | Total |
|---|---|---|---|---|
| Age, Continuous | 35.4 years | 39 years | 39 years | 37.8 years |
| Ethnicity (NIH/OMB) Hispanic or Latino | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 19 Participants | 32 Participants | 60 Participants | 111 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 19 Participants | 32 Participants | 60 Participants | 111 Participants |
| Race (NIH/OMB) Black or African American | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) White | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Sex: Female, Male Female | 9 Participants | 20 Participants | 20 Participants | 49 Participants |
| Sex: Female, Male Male | 10 Participants | 12 Participants | 40 Participants | 62 Participants |
| Stigma score | 2.2358 score STANDARD_DEVIATION 0.56062 | — | — | 2.2358 score STANDARD_DEVIATION 0.56062 |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 19 |
| other Total, other adverse events | 0 / 19 |
| serious Total, serious adverse events | 0 / 19 |
Outcome results
Change in Stigma Score From Baseline to End of Intervention in Protocol Group
Perceived Stigma Scale (PSS). Each item is measured using a 4-point Likert scale and the scale contains four factors: personalized stigma (18 items, subscore total 18-72), disclosure concerns (12 items, subscore total 12-48), negative self-image (9 items, subscore total 9-36), and concern with public attitudes about people with HIV (12 items, subscore total 12-48). Each factor is scored separately, with total score is computed by summing all 40 items, with a minimum total PSS score of 40 and a maximum possible score of 160. Raw PSS scores were transformed into Stigma scores 1-4. Higher scores reflect higher levels of perceived stigma.
Time frame: Baseline and 8 weeks
Population: Single-arm analysis was conducted in the protocol group.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Protocol group | Change in Stigma Score From Baseline to End of Intervention in Protocol Group | Pre-test stigma score | 2.2358 score | Standard Deviation 0.56062 |
| Protocol group | Change in Stigma Score From Baseline to End of Intervention in Protocol Group | Post-test stigma score | 2.1760 score | Standard Deviation 0.69976 |
Change in QOL Score From Baseline to End of Intervention in the Protocol Group
Cognitive and Affective Mindfulness Scale-Revised (CAMS-R) is a 12-item questionnaire that was used as a proxy measure of QOL in the study. Total maximum score of CAMS-R is 48 and minimum score is 12. Raw CAMS-R scores were transformed into QOL scores 0-3. Higher scores reflect better QOL.
Time frame: Baseline and 8 weeks
Population: Single-arm analysis was conducted in the protocol group.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Protocol group | Change in QOL Score From Baseline to End of Intervention in the Protocol Group | Pre-test QOL score | 2.73 score | Standard Deviation 0.82 |
| Protocol group | Change in QOL Score From Baseline to End of Intervention in the Protocol Group | Post-test QOL score | 2.68 score | Standard Deviation 0.9 |