Fatty Liver, Psoriasis
Conditions
Brief summary
Several recent reports have shown an increased prevalence of nonalcoholic fatty liver disease (NAFLD) in those with psoriasis, which may reflect the increased occurrence of metabolic syndrome in this patient population.
Detailed description
the recruitment of 60 fatty live men with chronic disease, psoriasis, will be classified to lifestyle modification group (foe 12 weeks, this patients will take supervised energy or diet restriction program plus their usual immunosuppressive drugs ) and control group will continue their drug program only)
Interventions
OTHERlifestyle modification
for 12 week, the patients of this group will receive their usual immuno-modulating therapy plus life style modification (energy or diet restriction in addition to daily walking, 15000 steps)
OTHERusual lifestyle
the patients will receive the usual immuno-modulating therapy with continued usual diet and activities
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* psoriasis obese patients with coexisting fatty liver * chronic plaque psoriasis * patients who will not show any change in immuno-modulating psoriasis therapies for at least five months before participation in the study.
Exclusion criteria
* no metabolic syndrome * no renal or cardiac or pulmonary disorders * other types of psoriasis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Psoriasis Area and Severity Index | It will be measured after 12 weeks | it is an index used to measure level and severity of psoriasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| triglycerides | It will be measured after 12 weeks | will measured in plasma |
| AST | It will be measured after 12 weeks | it is plasma aspartate transaminase |
| Dermatology Life Quality Index | It will be measured after 12 weeks | it is a questinnaire used to assess life quality in psoriasis humans |
| BMI | It will be measured after 12 weeks | it is body mass index |
| waist circumference | It will be measured after 12 weeks | it will be measured at the level of umbilicus |
| ALT | It will be measured after 12 weeks | it is plasma Alanine transaminase |
Countries
Egypt
Contacts
Primary ContactAli Ismail, lecturer
Outcome results
None listed