Post-COVID-19
Conditions
Keywords
SARS-CoV-2 infection, REM sleep, Chronic fatigue, Whoop strap, Polysomnography
Brief summary
After acute infection, patients with coronavirus disease 2019 (COVID-19) often suffer from persisting symptoms for more than 3 months (post COVID-19). Sleep disorders (31%) have already been assessed by questionnaires and interviews in post-COVID-19, but have not yet been proven by polysomnography (PSG), the gold standard for sleep testing. This study aimed to measure sleep characteristics in post-COVID-19 patients.
Detailed description
Hypothesis: We hypothesize that post-COVID-19 patients have a significantly higher apnea-hypopnea index (AHI) during sleep compared to healthy controls. 15 post-COVID-19 patients and 15 healthy controls will perform a baseline assessment on day 1 including a 1-minute sit-to-stand test (STST), post-COVID functional scale (PCFS), Ordinal Scale for Clinical Improvement (OSCI), history of COVID-19, social anamnesis, Pittsburgh Sleep Questionnaire and subjective limitations of sleep. On day 4, after an initialization phase for WHOOP strap (a digital fitness and health coach), all patients performed a single night sleep assessment in a sleep lab via Polysomnography and WHOOP.
Interventions
DIAGNOSTIC_TESTSleep diagnostics
On study day 4, all participants perform a single night sleep assessment in a sleep lab via Polysomnography (PSG) and WHOOP strap, a digital Fitness and health Coach.
Sponsors
Schön Klinik Berchtesgadener Land
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Inclusion criteria
Post-COVID-19 Group: * Patients after SARS-CoV-2 infection with signs of Post-COVID-19 * ≥18 years * written informed consent Healthy controls: * No history of SARS-CoV-2 infection * ≥18 years * written informed consent
Exclusion criteria
Post-COVID-19 Group: * Diagnosis of a breathing-related sleep disorder before SARS-CoV-2 infection * BMI \>25kg/m2 Healthy controls: * Diagnosis of a breathing-related sleep disorder * BMI \>25kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Apnea-Hypopnea-Index (AHI) | One single night on study day 4 | Number of apnea or hypopnea Events per hour of sleep |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Deep sleep phase | One single night on study day 4 | Duration of deep sleep Phase (minutes) |
| Light sleep phase | One single night on study day 4 | Duration of light sleep Phase (minutes) |
| Periodic leg movement Index | One single night on study day 4 | Number of Periodic leg movements per hour of sleep |
| Rapid Eye Movement (REM) sleep phase | One single night on study day 4 | Duration of REM sleep Phase (minutes) |
| Central apnea | One single night on study day 4 | Number of central apnea Events per night |
| Mixed apnea | One single night on study day 4 | Number of mixed apnea Events per night |
| Obstructive apnea | One single night on study day 4 | Number of obstructive apnea Events per night |
Countries
Germany
Outcome results
None listed