Age-related Cognitive Decline
Conditions
Keywords
Exercise, Mindfulness, Education, Elderly
Brief summary
This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.
Interventions
BEHAVIORALMindfulness-Based Stress Reduction
Mindfulness-Based Stress Reduction
BEHAVIORALExercise
Exercise
BEHAVIORALMindfulness-Based Stress Reduction + Exercise
Mindfulness-Based Stress Reduction + Exercise
BEHAVIORALHealth Education
Health Education
Sponsors
Washington University School of Medicine
University of California, San Diego
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participated in the parent study, Protocol ID #201410093
Exclusion criteria
* Inability to safely continue classes or complete assessments, as per PI discretion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of the interventions on changes in cognitive performance | Approximately three years | Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATOREric J Lenze, MD
Washington University School of Medicine
Outcome results
None listed