Coronary Artery Disease
Conditions
Keywords
PCI, CABG, HCR, Complex coronary artery disease
Brief summary
Coronary heart disease is one of the most serious diseases that endanger people's health. Complex coronary artery disease is critical and has high mortality. Therefore, it is urgent to explore the best treatment method for complex coronary artery disease. Some previous studies have shown that patients with left main coronary artery disease with a SYNTAX score\> 32 points, and diabetic/non-diabetic three-vessel disease patients with coronary heart disease with a SYNTAX score \> 22 points, CABG is recommended for revascularization. However, with the continuous innovation of surgical technology and the rapid development of surgical instruments, the treatment of patients with complex coronary artery disease is increasing. Therefore, it is necessary to investigate the effects of different revascularization strategies on long-term prognosis in patients with complex coronary artery disease (SYNTAX score \> 22 points).
Interventions
PROCEDUREThe procedures include PCI, CABG and HCR
The procedures include PCI, CABG and HCR
Sponsors
Beijing Anzhen Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Male/female aged 18-80 years; 2. Having complex coronary artery disease (SYNTAX score \> 22 points) undergoing myocardial revascularization
Exclusion criteria
1. Cardiogenic shock or hemodynamic instability; 2. Undergoing other heart surgery at the same time; 3. Previous coronary artery bypass surgery; 4. History of cerebral hemorrhage; 5. Ischemic stroke in the past six months; 6. History of cancer; 7. Life expectancy no more than 12 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MACCE | 1 year | Major adverse cardiovascular and cerebrovascular events (MACCE) at 1 year, including all-cause death, non-fatal myocardial infarction, ischemia-driven revascularization, and non-fatal stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular death | 1 year | Cardiovascular death |
| Non-fatal myocardial infarction | 1 year | Non-fatal myocardial infarction |
| Ischemia-driven revascularization | 1 year | Ischemia-driven revascularization |
| Non-fatal stroke | 1 year | Stroke is defined as a neurological deficit with symptoms or signs that last at least 24 hours and imaging studies (CT or MRI) confirm the presence of cerebral infarction or cerebral hemorrhage. |
| All cause death | 1 year | All-cause death is defined as death from cardiovascular causes, death from non-cardiovascular causes, and death from unknown causes. |
| The composite endpoints including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke | 1 year | The composite endpoints including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke |
| The composite endpoints including cardiovascular death or nonfatal myocardial infarction | 1 year | The composite endpoints including cardiovascular death or nonfatal myocardial infarction |
| All bleeding events defined by the BARC bleeding criteria | 1 year | All bleeding events defined by the BARC bleeding criteria |
| Type 2, 3 and 5 bleeding events defined by the BARC bleeding criteria | 1 year | Type 2, 3 and 5 bleeding events defined by the BARC bleeding criteria |
| The composite endpoints including all-cause death, non-fatal myocardial infarction, and ischemia-driven revascularization | 1 year | The composite endpoints including all-cause death, non-fatal myocardial infarction, and ischemia-driven revascularization |
Contacts
Primary ContactMiao Yu, Doctor
Outcome results
None listed