Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring

Comparison of Onset of Neuromuscular Blockade With Electromyographic and Acceleromyographic Monitoring: A Prospective, Randomized Trial

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05120999

Enrollment

100

Registered

2021-11-16

Start date

2021-10-25

Completion date

2022-01-14

Last updated

2023-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuromuscular Blockade

Keywords

neuromuscular blockade

Brief summary

The purpose of this research is to use 2 devices to compare the difference in the amount of time it takes for each device to register complete muscle relaxation after the muscle relaxing medication is given. The comparison will be made by using electromyographic (EMG), such as TetraGraph, and acceloromyographic (AMG), such as TOFScan, monitors at the time of insertion of breathing tube.

Interventions

DEVICETrain of four measurement

Use of either TetraGraph or TOFScan to measure the neuromuscular blockade

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients willing to participate and provide an informed consent. * Patients undergoing elective surgical procedures that require use of NMBA agents (rocuronium) administered intraoperatively.

Exclusion criteria

* Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury. * Patients with systemic neuromuscular diseases such as myasthenia gravis. * Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents; i.e., severe renal impairment or end-stage liver disease. * Patients having surgery that would involve prepping the arm into the sterile field. * Patients receiving a rapid sequence induction.

Design outcomes

Primary

Measure	Time frame	Description
Time difference	During the initiation of anesthesia period	Compare time difference from neuromuscular blockade agent administration to neuromuscular blockade onset

Secondary

Measure	Time frame	Description
Intubating conditions	During the initiation of anesthesia period	Assess intubating conditions once a complete neuromuscular blockade has been achieved either by TetraGraph or TOFScan measurements

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 11, 2026