Pediatric Cancer
Conditions
Brief summary
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
Detailed description
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG). This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) used for future biological studies and preclinical drug testing.
Interventions
OTHERCollection of post mortem tissue donation
Collection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained.
Sponsors
Ann & Robert H Lurie Children's Hospital of Chicago
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology) * Signed consent for post mortem tissue donation and autopsy
Exclusion criteria
* Signed consent for post mortem tissue donation and autopsy not obtained
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent | Up to 5 years from procurement | Procurement of pediatric cancer and non-cancer tumor tissue during autopsy with signed consent. Tissue will be collected through a research tissue collection autopsy of the original tumor and other sites that are appropriate. Samples of both tumor and normal cells will be collected in addition to body fluids such as cerebrospinal fluid (CSF), blood, bone marrow, and skin biopsies for genomic testing. |
Countries
United States
Contacts
CONTACTAngela Waanders, MD
CONTACTMelissa Williams, BA
PRINCIPAL_INVESTIGATORAngela Waanders, MD
Ann & Robert H Lurie Children's Hospital of Chicago
Outcome results
None listed