Osteoporosis
Conditions
Brief summary
The primary aim of the current research project is to explore whether carnitine supplementation and resistance training may prevent decrements in bone mineral density of aged women. A secondary aim of this project is to investigate the effect of supplementation on body composition and blood markers.
Detailed description
The study includes postmenopausal women. The subjects participate in resistance training (twice a week) for each session consisted of 6 exercises: horizontal seated leg press, seated chest press, leg extension, shoulder press, lat pull-down seated row, seated cable row. During the 24-weeks training programme participants are supplemented by carnitine with leucine, or leucine alone (placebo).
Interventions
DIETARY_SUPPLEMENTL-carnitine
L-carnitine-L-tartrate
DIETARY_SUPPLEMENTL-leucine
L-leucine
Sponsors
Medical University of Gdansk
Poznan University of Physical Education
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
60 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* postmenopausal * lack of restrictions to perform resistance exercises
Exclusion criteria
* cardiovascular disease * liver disease * kidney disease * neuromuscular disease * gastrointestinal disorders (including stomach ulcers and erosions) * diabetes * other severe chronic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone Mineral Density measured by dual-energy X-ray absorptiometry (DXA) | 24 weeks | Bone mineral density (BMD) of the femoral neck, lumbar vertebrae L1-L4, and total hip determined by Lunar Prodigy Advance DXA (GE, Healthcare, Madison, Wisconsin, USA). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body Composition: Body Fat Mass, Fat Free Mass, and Skeletal Muscle Mass using a bioelectrical impedance analyzer (InBody720). | 24 weeks | The InBody720 measures impedance of five segments of the body (each arm, each leg, trunk) at frequencies of 1, 5, 50, 250, 500, and 1000 kHz through the 8-polar tactile-electrode. Based on the impedance, body fat mass, fat free mass, and skeletal muscle mass are calculated. |
| The circulating markers modification | 24 weeks | Determination of serum interleukin-6, tumor necrosis factor alpha, C-reactive protein, and plasma trimethylamine N-oxide. |
Countries
Poland
Outcome results
None listed