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Gut Microbiota Stunted Children NTT

Gut Microbiota Profile, SCFA, Gut Integrity, Parasite Infection, Hygiene Practice and Cognitive Score on Stunted Children in East Nusa Tenggara

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05119218
Enrollment
200
Registered
2021-11-15
Start date
2021-11-02
Completion date
2022-02-20
Last updated
2022-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stunting

Keywords

stunting, Gut microbiota, toddler, SCFA, Parasite, Hygiene Practice

Brief summary

NTT Province is on the list of priority areas of high prevalence of stunting, Southwest Sumba, South Middle East, and Kupang district have a stunting prevalence of 36.2%, 34.5% and 48.1% respectively in 2020. Therefore, it is necessary to conduct a profile study. microbiota, SCFA, gastrointestinal integrity, parasites, hygiene practice, and cognition in stunting and healthy toddlers in the province of East Nusa Tenggara,

Detailed description

Stunting indicates a public health problem because it is associated with an increased risk of morbidity and mortality, decreased motor and mental function development, and reduced physical capacity. Stunting is a chronic nutritional deficiency condition that affects the growth and development, and intelligence of children. Lack of nutrients can cause intestinal microbiota dysbiosis where this will reduce the metabolism of short chain fatty acids (SCFA) which will affect the absorption of nutrients in the small intestine and cause impaired immunity, which in turn worsens stunting conditions. The composition of the gut microbiota is influenced by age, sex, geographic area and food intake. Therefore, the description of knowledge, attitudes and applications in society, especially mothers and child subjects, was also analyzed using a hygiene practice questionnaire. The aim of the study was to obtain an overview of the gut microbiota, gastrointestinal integrity, parasitic infections, hygiene practices and cognitive scores in stunting and healthy toddlers in several areas in the province of East Nusa Tenggara as a baseline study to be followed up by intervention study. The research will be conducted for 3 (three) months in 2021/2022. The subjects involved represented 100 stunted children and 100 healthy children aged 36-45 months from each region. Determination of the sample with a sampling quota. The variables studied were the nutritional status of under five years children, characteristics of children under five (age, gender, birth weight (BBL), birth length, breast feeding history, immunization history, history of diarrhea, history of ARI (Upper Respiratory Tract Infection)), mother and family characteristics (age, education). , occupation, father's occupation, total family income), home environment and hygiene, vaccination history, gastrointestinal microbiota status, gastrointestinal integrity, parasites, hygiene practices, and cognitive scores.

Interventions

OTHERNo Intervention

No Intervention

Sponsors

Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia
CollaboratorOTHER_GOV
Maastricht University
CollaboratorOTHER
Universitas Airlangga
CollaboratorOTHER
Yarsi University
CollaboratorUNKNOWN
Universitas Kristen Indonesia
CollaboratorOTHER
Bina Nusantara University
Lead SponsorOTHER

Study design

Observational model
FAMILY_BASED
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
36 Months to 45 Months
Healthy volunteers
Yes

Inclusion criteria

* Anthropometric measurements of stunting were measured based on the parameters of length/height according to age compared to the 2005 WHO anthropometric standards and the Indonesian Ministry of Health Decree No. 1995/MENKES/SK/XII/2010.

Exclusion criteria

* criteria thats makes subject appropiate, like more than 5 years old, not live in sampling area, unhealthy

Design outcomes

Primary

MeasureTime frameDescription
200 sample Gut Microbiota Profile descript OTU by NGS2 monthsProfile of genus microbiota observed using Next Generation Sequencing

Secondary

MeasureTime frameDescription
200 cognitive development data from coqnitive measurement2 monthscoqnitive descriptive
200 sample Short Chain Fatty Acid Profile from feses sample1 monthsmicrobiota metabolite profile
200 sample Gut Integrity profile from blood sample2 monthsserum lipid binding protein, serum citrulline, serum Intestinal Fatty Acid Binding Protein (IFABP), serum Fatty Acid Binding Protein (FABP), sCD14, dan sCD163.
200 sample immune response from blood sample2 monthsTNF, TGF, IL-10, dan sIgA
200 data hygiene practice from quenstionare data2 monthsepidemiology data, daily hygiene practice, family data

Countries

Indonesia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026