Hyperglycemia
Conditions
Keywords
coffee, glucose challenge, blood glucose levels
Brief summary
The present study determined the effects light, medium, and dark roasted, brewed coffees on blood glucose responses in normal (n = 19) subjects.
Detailed description
This is a single-blinded, randomized partial block design conducted over 6 weeks in two parts. In part 1 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a beverage containing 50 g of glucose. In part 2 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a standardized breakfast (corn flakes cereal + skim milk) containing 50 g of glucose. In each part, fasting and postprandial glucose profiles were determined.
Interventions
DIETARY_SUPPLEMENTMedium Roasted Coffee
12 oz medium roast coffee
DIETARY_SUPPLEMENTDark Roasted Coffee
12 oz dark roast coffee
DIETARY_SUPPLEMENTPlacebo Comparator
Placebo designed to mimic coffee color.
DIETARY_SUPPLEMENTLight Roasted Coffee
12 oz light roast coffee
Sponsors
North Carolina State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
Subjects provided placebo and coffee beverages in a color coded bottles
Intervention model description
Randomized, single-blinded, partial block, crossover design
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
• Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.
Exclusion criteria
* Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl. * Weight less than 110 pounds (55 kg) * Pre-existing health conditions, such as: * High cholesterol * Hypertension * Cardiovascular disease * Gastrointestinal motility disorders * Hypo- or hyperthyroidism * Anemia * Renal disease * Liver disease, including hepatitis B or C, cholestasis, cirrhotic liver disease, or non-alcoholic fatty liver disease * Chronic or acute pancreatitis * Diabetes type 1 or 2 * Insulin resistance * Polycystic ovary syndrome * Food allergies or intolerances to coffee/caffeine/dairy/corn-based cereals. * Currently taking prescription medication * Current smoker * Consumes more than 3 alcoholic beverages per day * Pregnant or breastfeeding * Not willing to take their own blood samples with finger sticks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Blood Glucose | 6 weeks | Each week, fasted baseline and postprandial measurements taken out to 240 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Glucose Area Under the Curve | 6 weeks | Used glucose changes over 240 minutes to construct area under the curve |
Countries
United States
Outcome results
None listed