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Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Early Fluid Resuscitation in Patients With Septic Shock

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05118646
Enrollment
62
Registered
2021-11-12
Start date
2020-12-01
Completion date
2021-12-30
Last updated
2021-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

Septic shock; Sublingual Microcirculation

Brief summary

Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

Detailed description

Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock. Intervention: 1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%). 2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters. Primary outcome: (1)change in SOFA score at 72h (2)30-day mortality

Interventions

DEVICEsublingual microcirculation,

Avoiding pressure artifacts, clear stable microvascular images were taken for a minimum of 20 seconds of the left, middle, and right sections of the tongue.

DEVICEhemodynamic monitoring

Arterial blood lactic acid (Lac), central venous oxygen saturation (ScvO2), hematocrit (HCT) and entral venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2) will be measured employing a bedside blood gas machine on admission and six hours following admission.

Sponsors

Xiangya Hospital of Central South University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

* patients fulfilled the diagnostic criteria of septic shock.

Exclusion criteria

* declined to participate * pregnant * patients who were younger than 18 years old * active bleeding * septic shock is diagnosed for more than 4 hours * patients are expected to be die within 24hours

Design outcomes

Primary

MeasureTime frameDescription
change in SOFA score72h△SOFA

Secondary

MeasureTime frameDescription
30-day mortality30dmortality

Countries

China

Contacts

Primary ContactLina Zhang, MD.
zln7095@163.com+8615874875763

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026