Periprosthetic Joint Infection (PJI)
Conditions
Keywords
Infection Likely group, Infection Unlikely group, European Bone and Joint Infection Society (EBJIS), revision total hip arthroplasty (THA), revision total knee arthroplasty (TKA)
Brief summary
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).
Detailed description
Periprosthetic joint infection (PJI) is a major burden for healthcare systems. The European Bone and Joint Infection Society (EBJIS) proposed a new set of criteria introducing a three level 'traffic light' distinction: Infection Unlikely, Infection Confirmed but also an intermediate group called Infection Likely (but nor confirmed). This retrospective multi-center, multi-national cohort study is to validate the EBJIS Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).
Interventions
OTHERdata collection to classify infection status
Review of medical records of all selected cases (TKA/THA patients) to classify infection status according to different classifications (EBJIS, MSIS/ICM 2013, ICM 2018).
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* THA/TKA patients that underwent revision surgery regardless of final aseptic vs. infected diagnosis between 01.01.2013 until 31.12.2018
Exclusion criteria
* less than two years follow up * less than four intraoperative microbiology samples (synovial fluid, tissue samples, implant sonication) * no preoperative/intraoperative synovial fluid differential leukocyte count
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prosthetic Joint Infections (with or without the need for further surgery) | since 01.01.2013 with a minimum of two years follow up | Number of Prosthetic Joint Infections (with or without the need for further surgery) among each PJI definition (Infection Unlikely, Infection Confirmed, Infection Likely (but nor confirmed) |
| Need for Revision Surgery | since 01.01.2013 with a minimum of two years follow up | Number of Revision Surgeries (for all causes, PJI and aseptic failure) among each PJI definition (Infection Unlikely, Infection Confirmed, Infection Likely (but nor confirmed) |
| Survival rates of different subgroups among each PJI definition | since 01.01.2013 with a minimum of two years follow up | Survival rates of different subgroups among each PJI definition (Infection Unlikely, Infection Confirmed, Infection Likely (but nor confirmed) |
| Survival rates between different definitions | since 01.01.2013 with a minimum of two years follow up | Survival rates between different classifications (EBJIS, MSIS/ICM 2013, ICM 2018). |
Countries
Portugal, Switzerland
Outcome results
None listed