Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05116150

Enrollment

Registered

2021-11-10

Start date

2019-06-01

Completion date

2019-12-01

Last updated

2021-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dietary Supplementation

Brief summary

This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.

Detailed description

The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.

Interventions

DIETARY_SUPPLEMENTGrape seed extract

Effects of 7 days of combined GSE with L-citrulline supplementation on hemodynamic responses at rest and during cycling exercise.

DIETARY_SUPPLEMENTPlacebo

Effects of 7 days of placebo supplementation on hemodynamic responses at rest and during cycling exercise.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy males

Exclusion criteria

* cardiovascular and/or pulmonary disease, musculoskeletal disorders, or medications that prevent the safe completion of the exercise protocol

Design outcomes

Primary

Measure	Time frame	Description
Systolic blood pressure (mmHg)	7 days	by sphygmomanometer
Diastolic blood pressure (mmHg)	7 days	by sphygmomanometer
Mean arterial pressure (mmHg)	7 days	calculated (MAP = (SBP-DBP)/3 + DBP
Heart rate (bpm)	7 days	measured using Physio Flow (non-invasive device)
Stroke volume (ml)	7 days	measured using Physio Flow (non-invasive device)
Cardiac output (l/min)	7 days	calculated: HR (bpm) x SV (ml)
Total vascular conductance (ml/min/mmHg)	7 days	calculated: CO (ml/min) / MAP (mmHg)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026