ARDS Due to Severe Acute Respiratory Syndrome Coronavirus 2
Conditions
Brief summary
The best way to titrate positive end-expiratory pressure (PEEP) in patients suffering from acute respiratory distress syndrome is still matter of debate. Electrical impedance tomography (EIT) in a non-invasive technique that could guide PEEP setting based on an optimized ventilation homogeneity.
Detailed description
COVID-19 related ARDS patients admitted to the ICU in March 2021 requiring mechanical ventilation were enrolled. Patients were monitored by an esophageal catheter and a 32-electrode EIT device. Within 48 hours after the start of mechanical ventilation, different levels of PEEP were applied based upon PEEP/ Fraction of inspired oxygen tables, positive end-expiratory transpulmonary (PL)/ FiO2 table, and EIT. Respiratory mechanics variables were recorded.
Interventions
OTHERPEEP setting
PEEP setting according to various methods
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* COVID19-related ARDS under invasive mechanical ventilation
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Value of PEEP | a single determination, within 24-48 hours after mechanical ventilation initiation | different PEEP values obtained through using different methods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory mechanics | a single determination, within 24-48 hours after mechanical ventilation initiation | Respiratory mechanics (plateau pressure, driving pressure, compliance, mechanical power) following different PEEP settings |
Countries
France
Outcome results
None listed