Migraine, Multiple Sclerosis, Small Vessel Ischemic Disease
Conditions
Brief summary
The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraines
Interventions
DIAGNOSTIC_TESTBrain Neuroimaging
Non-invasive magnetic resonance imaging sequences will investigate metabolic signatures unique to migraine WMH. Imaging data will be used for development of artificial intelligence (AI) algorithms to classify the cause of WMHs.
Sponsors
Mayo Clinic
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
- Migraine (N=20): * Female only. * Ages 20-45 years. * Presence of WMH on MRI.
Exclusion criteria
* History of SVI and/or history of MS or other neurological disease other than migraine. * History of cancer or organ transplantation. * Contraindication to MRI. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study. Inclusion Criteria - SVI disease (n=10): * Female only * Ages \> 60 years. * Presence of WMH on MRI.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| WMH imaging disease parameters | 3 months | Radiological MRI assessment of WMH in migraine |
Countries
United States
Outcome results
None listed