Management of Robertsonian Translocation PGT-SR Attempts

New Recommendations for Robertsonian Translocation Management After Preimplantation Genetic Testing of Structural Rearrangement (PGT-SR) Attempts: What Should be Done With Mosaic Embryos?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05109962

Enrollment

148

Registered

2021-11-05

Start date

2006-01-01

Completion date

2018-12-01

Last updated

2021-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Robertsonian Translocation

Keywords

Several years of miscarriages, Abortions and primary infertility, FISH with 2 probes, FISH with 3 probes

Brief summary

to analyze if a probe strategy choice for PGT-SR studies of Robertsonian translocations (RT) influences the fate of embryos? Few studies discussed the importance of probe choices. However, those who did, demonstrated that analysis with locus specific probes improve a diagnosis of dubious results, and addition of a centromeric probe could affect the accuracy of diagnosis

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patient whom carrying robertsonian translocations in the context of PGT-SR management * age \> 18 years

Exclusion criteria

\- age \< 18 years

Design outcomes

Primary

Measure	Time frame	Description
Number of Participants with detect all chromosome segments	1 day	Number of Participants with detect all chromosome segments

Countries

France

Outcome results