Prostate Hyperplasia
Conditions
Brief summary
Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.
Detailed description
Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.
Interventions
PROCEDURESurgery method
Patients were subdivided into two groups according to their prostate volume
Sponsors
Adana City Training and Research Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
MALE
Healthy volunteers
No
Inclusion criteria
* ASA scores I-III patients * having benign prostatic hyperplasia * undergoing HOLEP or TURP surgery under general anesthesia
Exclusion criteria
* immune system disease, * diabetes mellitus, * malignancy other than prostate disease, * history of steroid use,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| stress hormone levels | Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour | Cortisol (microg/dl) |
| inflamatory markers | Change from baseline WBC (109 /L) at postoperative 0th and postoperative 24th hour | WBC (109 /L) |
| Stress hormone levels | Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour | Adrenaline (ng/L) |
Countries
Turkey (Türkiye)
Outcome results
None listed