Quadriceps Femoris Measurement as a Surrogate of Muscle Mass Assessment in Critically Ill Children
Conditions
Keywords
Ultrasound;, Magnetic resonance imaging;, quadriceps femoris,, critically ill children
Brief summary
A vast majority of children admitted to paediatric intensive care (PICU) present with faltering growth during their admission. Muscle mass loss is an early, intense and frequent phenomenon in this setting, which is associated with impaired outcomes. Recent international guidelines recommend monitoring both nutritional status and muscle mass throughout hospital stay. Recent studies have used quadriceps femoris (QF) measurements as a surrogate for lean mass assessment, and monitored them with bedside ultrasound (QF thickness and QF cross sectional area). However, ultrasound cross sectional area inter-operator reproducibility has not been validated so far, and none of these ultrasound measurements has been validated against their gold standard i.e. magnetic resonance imaging measurements. This validation process should be conducted to allow interpreting ultrasound muscle measurements, prior to the implementation of ultrasound measurments into clinical practice. We hypothesise that ultrasound measurements of QF thickness and cross sectional area are reliable compared to the magnetic resonance imaging gold standard, and that QF cross sectional area has a reliable inter-operator reproducibility.
Interventions
OTHERUltrasound and magnetic resonance imaging measurements of quadriceps femoris
In sedated critically ill children, quadriceps femoris thickness and cross sectional area will be measured with thigh bedside ultrasound, performed by two trained operators consecutively. These two measurements will also be made at the exact same location on a magnetic resonance imaging transverse view of the thigh, to allow comparing them to ultrasound measurements.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* critically ill children from 0 to 17 years old * magnetic resonance imaging planned for any medical reason * sedated child for any medical reason * absence of parental/patient refusal to participate to the study
Exclusion criteria
* congenital neuromuscular disease * no possible access to the thigh (e.g. dressing, drains, gypsum) * anatomical anomaly of the limb, that would compromise localizing thigh landmarks (patella, groin) * inability to obtain limb rest and/or thigh muscle decontraction * risk induced by mobilization of the patient for ultrasound or magnetic resonance imaging purpose * absence of social insurance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intraclass correlation coefficient between ultrasound measurements and magnetic resonance imaging measurements | All ultrasound measurements will be made the same day than the magnetic resonance imaging, in a 6 hour-range prior or after the magnetic resonance imaging. | The mean of 4 measurements of quadriceps femoris thickness and the mean of 3 measurements of quadriceps femoris cross sectional area, performed by ultrasound, will be compared with the measurements means performed by magnetic resonance imaging |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORVALLA Frédéric, Pr
Hospices Civils de Lyon
Outcome results
None listed