Macular Neovascularisation
Conditions
Brief summary
The aim of study is to compare the evaluation of dark halo area of macular neovascularization (MNV) between indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in order to identify OCTA as effective and useful biomarker in MNV
Detailed description
Dark halo is defined as a dark perilesional of flow decrease due to an area of reduced choroidal flow adjacent to the macular neovascularization (MNV). The detection of MNV vascular details was only possible through invasive dye injection, such as fluorescein angiography (FA) or indocyanine green angiography (ICGA). Optical coherence tomography angiography (OCTA) is a recent imaging technique that is able to detect the perfusion and non-perfusion areas carefully. The aim of study is to compare the evaluation of dark halo area of MNV between ICGA and OCTA
Interventions
DIAGNOSTIC_TESTOptical Coherence Tomography Angiography (OCTA) and indocyanine green angiography (ICGA)
OCTA and ICGA is able to detect the dark halo as a area of reduced perfusion around MVN
Sponsors
Federico II University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age older than 55 years * diagnosis of macular neovascularization * absence of previous treatment with anti-Vegf injections * absence of other retinal vascular diseases
Exclusion criteria
* age younger than 55 years * absence diagnosis of macular neovascularization * presence of previous treatment with anti-Vegf injections * presence of other retinal vascular diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dark halo measurement | three years | The OCTA and ICGA parameters analyzed are: the area of dark halo (mm2) that surrounds the coroidal neovascularization. |
Countries
Italy
Outcome results
None listed