Mild Cognitive Impairment
Conditions
Brief summary
This project is focused on conducting a home-based, thinking while moving exercise intervention for adults 65 years or older, who have mild cognitive impairment, that will integrate several effective training modalities including non-contact cardio-kickboxing, stepping exercise, balance/functional training, and muscle strengthening. Cognitive function, physical function, and dual-task abilities will be assessed over the 12-week intervention and comparisons will be made between participants in the exercise intervention and control participants receiving no intervention.
Interventions
BEHAVIORALDual-Task Exercise Training
Simultaneous cognitive-motor training
Sponsors
National Center for Advancing Translational Sciences (NCATS)
State University of New York at Buffalo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 65 years or older * Male or female * Screened positive for mild cognitive impairment (Montreal Cognitive Assessment score 23 to 26 points * Having no absolute contraindications to non-physician supervised exercise.
Exclusion criteria
* Lower-body amputation * Non-English language speaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Balance: Left Limb | Pre-test (time 0) and End point (12 weeks) | Change in performance on the Four-Stage Balance Test: Left Limb. Minimum value: 0 seconds Maximum value: 10 seconds Higher score = better performance |
| Change in Balance: Right Limb. | Pre-test (time 0) and End point (12 weeks) | Change in performance on the Four-Stage Balance Test: Right Limb. Minimum value: 0 seconds Maximum value: 10 seconds Higher score = better performance |
Countries
United States
Participant flow
Recruitment details
Recruitment took place from September 1st 2021 through May 21st, 2022 in local community centers, churches, and senior centers.
Participants by arm
| Arm | Count |
|---|---|
| Dual-Task Training Dual-Task Exercise Training: Simultaneous cognitive-motor training | 9 |
| Control Received no exercise guidance | 7 |
| Total | 16 |
Baseline characteristics
| Characteristic | Dual-Task Training | Control | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 9 Participants | 7 Participants | 16 Participants |
| Age, Categorical Between 18 and 65 years | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Black or African American | 2 Participants | 1 Participants | 3 Participants |
| Race (NIH/OMB) More than one race | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) White | 7 Participants | 6 Participants | 13 Participants |
| Sex: Female, Male Female | 5 Participants | 5 Participants | 10 Participants |
| Sex: Female, Male Male | 4 Participants | 2 Participants | 6 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 9 | 0 / 7 |
| other Total, other adverse events | 0 / 9 | 0 / 7 |
| serious Total, serious adverse events | 0 / 9 | 0 / 7 |
Outcome results
Primary
Change in Balance: Left Limb
Change in performance on the Four-Stage Balance Test: Left Limb. Minimum value: 0 seconds Maximum value: 10 seconds Higher score = better performance
Time frame: Pre-test (time 0) and End point (12 weeks)
Population: Older adults with MCI.
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Dual-Task Training | Change in Balance: Left Limb | 1.52 Seconds |
| Control | Change in Balance: Left Limb | 0.05 Seconds |
Comparison: Change in balance was assessed by calculating a change score between pre-test and end point scores for balance. Change scores were then compared using Mann-Whitney U test and reported as Median (Interquartile range).p-value: 0.001Wilcoxon (Mann-Whitney)
Comparison: Change in balance was assessed by calculating a change score between pre-test and end point scores for balance. Change scores were then compared using Mann-Whitney U test and reported as Median (Interquartile range).p-value: 0.003Wilcoxon (Mann-Whitney)
Primary
Change in Balance: Right Limb.
Change in performance on the Four-Stage Balance Test: Right Limb. Minimum value: 0 seconds Maximum value: 10 seconds Higher score = better performance
Time frame: Pre-test (time 0) and End point (12 weeks)
Population: Older adults with MCI
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Dual-Task Training | Change in Balance: Right Limb. | 1.48 seconds |
| Control | Change in Balance: Right Limb. | 0.3 seconds |