Exercise, Muscle Fiber Type, Training Frequency
Conditions
Keywords
Strength training, Muscle typology
Brief summary
The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers. Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).
Interventions
OTHERMuscle typology + exercise training
Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.
OTHERMuscle typology + training frequency
Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.
Sponsors
University Ghent
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
The participants don't know their muscle typology during the study. All participants do the same training intervention, no drugs are taken.
Intervention model description
All participants will receive the same training intervention but the subjects are divided into two groups based on an inherent physiological characteristic: the muscle typology. A slow typology group (people with a lot of slow muscle fibers) and a fast typology group (people with a lot of fast muscle fibers). Each participant will train their legs and arms unilateral and one arm and one leg will train two times per week, while the other arm and leg will train three times per week for 9 weeks. The assignment of the limbs to the 3x/week condition and the 2x/week condition is randomized. The training outcomes of the two groups will be compared as well as the within subject differences between training two times per week or training 3 times per week.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Fast or slow muscle typology * 18 - 45 years old * no strength training experience
Exclusion criteria
* Vegan/vegeterian diet * Supplement intake * chronic diseases * Hypertension, * Smoking * Medication use * Coagulation disorder, infectious diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle fiber type specific hypertrophy at 9 weeks | Pre and post 9 weeks training period | Legs - Biopsy (vastus lateralis) |
| Change from baseline muscle volume at 9 weeks | Pre and post the 9 weeks training period | Muscle volume of the legs and the upper arms - MRI |
| Change from baseline dynamic muscle strength at 3 weeks | Pre, mid and post 9 weeks training period | Upper legs and upper arms - strength training devices |
| Change from baseline dynamic muscle strength at 6 weeks | Pre, mid and post 9 weeks training period | Upper legs and upper arms - strength training devices |
| Change from baseline dynamic muscle strength at 9 weeks | Pre, mid and post 9 weeks training period | Upper legs and upper arms - strength training devices |
| Change from baseline isometric muscle strength at 9 weeks | Pre and post 9 weeks training period | Upper legs and upper arms - Biodex |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of baseline skeletal muscle protein content at 9 weeks | Pre and post 9 weeks training period | Histochemistry and protein content of markers of relevance for skeletal muscle function |
| Change of baseline histochemistry at 9 weeks | Pre and post 9 weeks training period | Histochemistry of markers of relevance for skeletal muscle function |
| Change from basline fatigue feeling over 9 weeks training period | Assessed every training during the 9 weeks training period | Number of repetitions during every training, questionnaire (VAS-scale) before every training, RPE after every training |
| Change from baseline fasting insulin, glucose, cholesterol and triglycerides at 9 weeks | Pre and post 9 weeks training period | Fasted blood samples |
| Change of baseline antropometry at 9 weeks | Pre and post 9 weeks training period | Height, weight, skinfolds |
Countries
Belgium
Outcome results
None listed