Overweight and Obesity
Conditions
Keywords
Eating, Overweight, Obesity, Food, Weight Loss, Magnetic Resonance Imaging, Neuroimaging, Brain, Body Weight
Brief summary
The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
Interventions
BEHAVIORALActive Implicit Priming
Approximately 10-minute behavioral intervention
BEHAVIORALControl Implicit Priming
Approximately 10-minute behavioral intervention
BEHAVIORALFood Exposure Task
Approximately 10-30 minute behavioral intervention
Sponsors
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-65 years old * BMI of 27 or greater
Exclusion criteria
* MRI contraindications (e.g., metal or electronic devices in the body) * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging | Baseline, 12 weeks | Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex. |
| Change in Food Image Ratings | Baseline, 12 weeks | Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat. |
| Change in Food Intake | Baseline, 12 weeks | Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percent Change in Body Weight | Baseline, 12 weeks | Percent change in body weight (kg) from baseline to after the 12-week intervention. |
| Change in Fat Mass | Baseline, 12 weeks | Change in fat mass, as measured using dual-energy x-ray absorptiometry, from baseline to after the 12-week intervention. |
Countries
United States
Contacts
CONTACTChristina Erpelding, BS
CONTACTKristina Legget, PhD
PRINCIPAL_INVESTIGATORJason Tregellas, PhD
University of Colorado, Denver
Outcome results
None listed