ST-Segment Elevated Myocardial Infarction
Conditions
Keywords
ST-segment elevated myocardial infarction, myocardial work, left ventricular remodeling
Brief summary
The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom; * Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.
Exclusion criteria
* significant valvular disease; * cardiomyopathy; l * left bundle branch block; * atrial fibrillation; * previous myocardial infarction (MI); * history of cardiac surgery; * pacemaker implantation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Delta-work efficiency by echocardiography | 24-72 hours after PCI | A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Global constructive work by echocardiography | 24-72 hours, 3-month after PCI | Global constructive work (GCW) was defined as work contributing to LV ejection performed during shortening in systole and work performed during lengthening in isovolumic relaxation. |
| Global work efficiency by echocardiography | 24-72 hours, 3-month after PCI | Global work efficiency (GWE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage. |
| Global work index by echocardiography | 24-72 hours, 3-month after PCI | Global work index (GWI) is classified as total work within the area of the LV pressure-strain loop calculated from mitral valve closure to mitral valve opening. |
| Constructive work-LAD | 24-72 hours, 3-month after PCI | constructive work in left anterior descending(LAD) territory. |
| Work efficiency-LAD | 24-72 hours, 3-month after PCI | Work efficiency in left anterior descending(LAD) territory. |
| Work index-LAD | 24-72 hours, 3-month after PCI | Work index in left anterior descending(LAD) territory. |
Countries
China
Outcome results
None listed