Inflammation
Conditions
Keywords
macrophage, inflammation, inflammation resolution
Brief summary
Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).
Interventions
PROCEDUREblood sample or joint fluid or gingival exudate
blood sample collected by peripheral blood mobilization joint fluid collected by punction gingival exudate collected with paper strips
Sponsors
Centre Hospitalier Universitaire de Besancon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Masking description
patients are anonymized
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age Limits (18-80 years) * Information and non-opposition for participating in the study * Patients suffering from periodontitis grade III ou IV * Patients suffering from microcristalline arthritis * patient with health insurance
Exclusion criteria
* patient under corticotherapy * pregnancy * non-compliant patient * patient with no health insurance * patient in exclusion period from an other study * legal incapacity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of cytokine concentrations in samples by ELISA | up to 2 months |
Countries
France
Contacts
Primary ContactThomas CHERRIER, MCU-PH
Outcome results
None listed