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Evaluation of a Free-breathing Cardiac Cine-MRI Sequence With Image Reconstructions by Deep-Learning in Ischemic Heart Disease

Evaluation of a Free-breathing Cardiac Cine-MRI Sequence With Image Reconstructions Developed by Deep-Learning Compared to the Classic Apnea Cine-MRI Sequence in the Assessment of Ischemic Heart Disease.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05105984
Acronym
CINEDL
Enrollment
54
Registered
2021-11-03
Start date
2022-04-14
Completion date
2024-01-29
Last updated
2025-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Magnetic Resonance Imaging, Deep-Learning, Left Ventricular Ejection Fraction, Magnetic Resonance Imaging

Keywords

Magnetic resonance imaging, Cardiac magnetic resonance imaging, Deep-Learning, Left ventricular ejection fraction, Left ventricular end systolic volume, left ventricular end diastolic volume

Brief summary

Today, MRI is the gold standard for the precise assessment of left ventricular volume and function, but presents the drawback of having a long acquisition time and of generating motion artifacts, in particular respiratory artifacts, requiring repeated sequences in apnea to cover the whole cardiac volume. These apneas are difficult to achieve in patients with ischemic heart disease and may lead to degradation of the images, an increase in the duration of the examination by repeated acquisitions and therefore to diagnostic inaccuracies. Artificial intelligence, already used in practice in cardiac MRI for automatic segmentation of the heart chambers, improves radiological interpretation with rapid and precise measurements. Deep-learning, which is part of artificial intelligence, would allow the reconstruction of cine-MRI sequences in free breathing, in order to overcome the artifacts from respiratory motions, and the improvement of diagnostic performance while improving examination conditions for patients. Patients coming for a cardiac MRI for the assessment of ischemic heart disease will be eligible to the protocol. If the patient agrees to participate, a free-breathing cardiac cine-MRI sequence with Deep Learning based image reconstruction will be added to the usual protocol. No follow-up will be required in this study.

Interventions

None listed

Sponsors

Centre Hospitalier Universitaire, Amiens
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age \> or = 18 years old * Ischemic heart disease * Ability of the subject to understand and express his consent * Affiliation to the social security scheme

Exclusion criteria

* Major obesity (\> 140kg) not allowing the patient to enter the tunnel of the machine whose diameter is less than 70cm * Under 18 years old * Pregnant woman * Known allergy to gadolinium chelates * Claustrophobia * Any contraindication to MRI * Arrhythmia * Difficulty in holding apneas of more than 10 seconds

Design outcomes

Primary

MeasureTime frameDescription
difference of LVEF measurements between Deep Learning reconstruction and the classic cine-MRI sequence5 minutesdifference of LVEF measurements between Deep Learning reconstruction and the classic cine-MRI sequence

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026