Induction of General Anesthesia
Conditions
Brief summary
This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.
Detailed description
This study aims to investigate the hemodynamic effects of both propofol and sevoflurane for induction of anesthesia in infants less than 3 months of age by electrical cardiometry. The investigators hypothesized that propofol will have a safe hemodynamic profile for induction of anesthesia in infants less than 3 months of age as measured by electrical cardiometry in addition to its favorable pharmacokinetic profile of rapid induction and optimal intubation conditions.It is conducted at Abu Al Reesh Children's Hospital, Faculty of Medicine, Cairo University based on an institutional protocol used as a standard of care to induce anesthesia
Interventions
DRUGPropofol
Intravenous induction of general anesthesia in infants 3 months or less.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Days to 90 Days
Healthy volunteers
No
Inclusion criteria
* infants aged 3 months or less scheduled for elective surgery
Exclusion criteria
* significant structural congenital heart disease * intracranial malformation. * preexisting hemodynamic instability. * history of seizures, opioids, and/or hypnotic administration. * prematurity (defined as gestational age \<37 weeks)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiac index | 15 minutes | L/min/m2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MAP | 15 minutes | mmHg |
Countries
Egypt
Contacts
Primary ContactShymaa Fathy, MD
Outcome results
None listed