Open Angle Glaucoma
Conditions
Keywords
Open angle glaucoma, Optical coherence Tomography, Photopic negative response
Brief summary
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
Detailed description
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects. OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
Interventions
DIAGNOSTIC_TESTOptical Coherence Tomography- Angiography
Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.
DIAGNOSTIC_TESTPhotopic negative response
Both the implicit time and amplitude of PhNR were recorded.
Sponsors
Benha University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Age of 30 years or older for both control and glaucoma groups. * Spherical equivalent (SE) between -2 and +2 D. * No history of previous eye surgery, trauma, or systemic diseases.
Exclusion criteria
* Spherical equivalent greater than +/- 2.00 diopters (D). * Media opacity as (cataract or corneal scar). * Any history of ocular surgeries or trauma. * Optic nerve anomaly or other retinal diseases. * Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between vascular, structural and functional changes of the peripapillary retinal nerve fiber and macular ganglion cell complex in patients with open angle glaucoma. | Immediately after OCTA and electroretinogram diagnostic tests for each eye. | Correlation between RNFL thickness and GCC measured by OCT-A with implicit time and amplitude of Photopic Negative Response (PhNR) measured by electroretinogram. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assess the validity of OCTA parameters and PhNR in early detection of glaucoma changes. | Immediately after OCTA and electroretinogram diagnostic tests for each eye. | Changes in the parameters were measured by OCT-A as Superficial and deep vessel Density. |
Countries
Egypt
Outcome results
None listed