Allergy, Fungal Allergy
Conditions
Keywords
Allergy, Fungal allergy, Alternaria alternata
Brief summary
Mold allergies are becoming increasingly important among the population. Increasing amounts of fungal spores are analyzed in air-samples because of urbanization, industrialization of food products and climate change. Mold also grows indoor and hence lead to additional health complaints. Alternaria alternata, and its only major allergen Alt a 1, is the most important fungus for allergy sufferers. Alternaria alternata can not only cause allergic symptoms but can also cause intensified asthmatic symptoms. Besides Alternaria alternata, there are over 700 other species of the genus Alternaria. The influence of these other species on allergic symptoms is poorly understood. Furthermore, prevalence and incidence of an allergy to Alternaria alternata among the Austrian population is not known. Estimates range between 1-5% among the Austrian population. This study aims to further investigate the incidence and characteristics of an allergy to Alternaria in Austria. This will be investigated with the help of participants (50 Alternaria allergy sufferers and 20 non allergic participants), spore counts in Austria and crowd-sourced symptom data.
Interventions
DIAGNOSTIC_TESTNasal provocation
Nasal provocation with Alternaria alternata extract. Changes in nasal mucosa are measured with a rhinomanometry device
DIAGNOSTIC_TESTSkin-Prick Test
Skin-Prick-Test is administered to determine an allergy against Alternaria
DIAGNOSTIC_TESTBlood draw
For further analysis
DIAGNOSTIC_TESTCollection of nasal secretion
Allergy sufferers: After nasal provocation Non-allergics: After administration of isotonic nasal spray
Sponsors
Medical University of Vienna
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants will be healthy people over 18 years of age. Allergic participants should have an allergic reaction against Alternaria, visible in the Skin-Prick-Test. Furthermore symptom data in the pollen diary of the Austrian Pollen Information Service should be existing
Exclusion criteria
* Subjects participating in a pharmacological study, pregnant subjects and subjects with an existing infectious- and/or autoimmune disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence, Immunoglobulin-E (IgE)-antibodies to selected Alternaria species | 12 months | Determine the prevalence of sensitization to multiple Alternaria species in the Austrian population |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cytokine-profile (e.g. Interleukin-13, Interleukin-5, Interleukin-10, TNFalpha, IFNgamma) upon Alt a 1 incubation | 12 months | Changes in the immun response when ligand-binding mononuclear cells from the blood to Alt a 1, characterized by the cytokine profile (Th1/Th2/regulatory) and the cell population (B- and T-cells, macrophages/monocytes) |
Countries
Austria
Contacts
Primary ContactMarkus Berger, Dr.
Outcome results
None listed