Anorexia Nervosa
Conditions
Keywords
Anorexia nervosa, metabolism, functional imaging, PET
Brief summary
The neuromolecular and metabolic underpinnings of Anorexia Nervosa (AN) are studied using multi-modal molecular (positron emission tomography with two different radioligands) and functional (functional magnetic resonance imaging) neuroimaging in a prospective design. Subjects with AN and normal weight adolescents will be studied with PET and MRI and followed for five years.
Detailed description
A total of sixty females (30 with AN, 30 healthy controls) are recruited into this prospective study. The subjects will undergo physical examination, body tissue composition measurement, functional and structural MRI of the brain and body, and positron emission tomography (PET) with ligands \[18F\]-FDG, and \[11C\]carfentanil. Subjects' weight and physical condition will be followed up for 5 years. The study will start in August 2020 and end in the fall of 2028.
Interventions
None listed
Sponsors
Turku University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 32 Years
Healthy volunteers
Yes
Inclusion criteria
for AN: 1. Female sex 2. Age 18-32 3 years 3. BMI \< 17.5 kg/m2 4. Currently fulfilling modified DSM-IV diagnosis of AN with or without amenorrhea, onset age before 25 years 5. Diagnosed less than 2 years ago For controls: 1. Female sex 2. Age 18-32 3 years 3. BMI 19 20-25 kg/m2 4. No lifetime history of obesity (BMI ≥\> 30) or eating disorders
Exclusion criteria
1. Any chronic disease or medication that could affect glucose metabolism or neurotransmission 2. History of psychiatric disorders (excl. AN for the corresponding study group) 3. Smoking of tobacco, taking of snuffs, or use of narcotics 4. Abusive use of alcohol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in brain reward system and metabolism in AN patients | 10 years | AN patients and controls are studied using fMRI and PET imaging and followed 10 years. Reward system function is measured using functional MRI and metabolism using 18F-fluorodeoxy glucose and PETCT imaging |
| Predictive value of baseline body mass index (BMI), functional brain activation and metabolism in AN | 10 y | Results from baseline are combined with follow updata |
Countries
Finland
Outcome results
None listed