Skip to content

Gingivitis and Periodontitis as a Risk Factor for Stroke

Gingivitis and Periodontitis as a Risk Factor for Stroke

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05101434
Enrollment
120
Registered
2021-11-01
Start date
2021-01-10
Completion date
2021-07-20
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis, Periodontitis, Stroke

Brief summary

Periodontitis and gingivitis are one of the most infectious diseases in humans. Several studies have been carried out on the dependence of periodontitis and stroke. The aim of this study was to investigate gingivitis and periodontitis as risk factors for stroke in the Pakistani population.

Detailed description

Epidemiologic studies have shown that cerebrovascular accident (CVA) is the 3rd cause of death in developed countries with 0.8 % prevalence in the whole population. Although, the prevalence rate of stroke is reduced yet is one of the most important health problems in the United State. Periodontitis and gingivitis are the two most infectious man diseases. Today, it is estimated that about 35% of people over 30-year-old in America and 50-55% of people in developing countries are involved with these diseases. These diseases are due to the practice of chronic bacterial infection and the inflammatory response of the host. The relationship between periodontitis and CVA was first introduced by Mackenzi and Millard in 1963 but the importance of this issue was not understood. Periodontal infection can be a complex multiphase disease by associating this infection with organ systems such as cardiovascular, endocrine, reproductive, and respiratory systems. Nowadays, periodontitis is considered a risk factor for atherosclerosis and thromboembolic disease.

Interventions

DIAGNOSTIC_TESTPeriodontal Probing

with the help Michigan probe, periodontal pocket measurement was done.

Sponsors

Shaheed Zulfiqar Ali Bhutto Medical University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Diagnosed stroke by using brain imaging from magnetic resonance imaging and/or computerized tomography.

Exclusion criteria

* Not willing to participate * Neurological complications other than stroke

Design outcomes

Primary

MeasureTime frameDescription
GingivitisbaselineMeasurement of bleeding site while probing and this was done with gingival index
PeriodonitisbaselineMeasurement of periodontal pockets while probing and this was done with community periodontal idex

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026