Coronary Artery Disease, Coronary Bifurcation Lesions
Conditions
Keywords
bifurcation lesions, percutaneous coronary intervention
Brief summary
Coronary bifurcation lesions are lesions (or blockages) that occur at or near the intersection of a major coronary artery and one of the arteries' side branches. Numerous techniques and devices have been developed to treat coronary bifurcations; however, these types of lesions remain some of the most challenging, both in terms of procedural success and outcome. This study is designed as an observational, multi-center registry that will collect information on treatment strategies and outcomes of consecutive patients undergoing percutaneous coronary interventions (PCI) in coronary bifurcations among various participating centers, in order to determine the frequency of bifurcation PCI, the procedural strategies utilized, and the procedural outcomes.
Detailed description
Numerous techniques and devices have been developed to treat coronary bifurcations; however, these types of lesions remain some of the most challenging, both in terms of procedural success and outcome. Several techniques are currently being utilized to treat coronary bifurcation lesions, including a 1-stent provisional stenting technique. Various 2-stent techniques are also performed, including: double kiss crush (DK crush4), culotte, T and protrusion (TAP), crush, mini-crush, reverse crush and V-stenting. The optimal technique for bifurcation stenting when two stents are required remains controversial; however, the DK crush technique appears to have stronger data, especially for left main bifurcations. However, DK crush can be challenging to perform, requiring several steps and frequent troubleshooting. The adoption of DK crush and other 2-stent bifurcation strategies, as well as the rigor of implementation, have received limited study. This study is designed as an observational, multi-center registry that will collect information on treatment strategies and outcomes of consecutive patients undergoing percutaneous coronary interventions (PCI) in coronary bifurcations among various participating centers, in order to determine the frequency of bifurcation PCI, the procedural strategies utilized,
Interventions
PROCEDUREPercutaneous Coronary Interbention
Percutaneous Coronary Interbention
Sponsors
Minneapolis Heart Institute Foundation
Study design
Observational model
CASE_ONLY
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Over 18 years of age * undergoing bifurcation percutaneous coronary intervention
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Procedural Success During Bifurcation PCI | From Date of Procedure to Date of Hospital Discharge, approximately 48-72 hrs after index procedure. | procedural success is defined as the absence of in-hospital major cardiac adverse events (MACE), including any of the following adverse events prior to hospital discharge: death, stroke, myocardial infarction, recurrent angina requiring urgent repeat target vessel revascularization with PCI or coronary bypass surgery, and tamponade requiring pericardiocentesis or surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Technical Success | From Date of Procedure to Date of Hospital Discharge, approximately 48-72 hrs after index procedure. | Technical success will be defined as successful bifurcation lesion recanalization by any method with achievement of \< 30% residual stenosis and TIMI 3 flow in both the main vessel and side branch. |
Countries
United States
Contacts
CONTACTEmmanouil Brilakis, MD, PhD
CONTACTBavana Rangan, BDS, MPH
Outcome results
None listed