Hyperoxia, Stress
Conditions
Keywords
oxidative stress markers, general anesthesia
Brief summary
The aim of the study was to assess the effect of intraoperative oxygen (O2), which was applied at 30% and 50% concentrations on patients who had undergone septoplasty surgery, on Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI).
Interventions
PROCEDUREtaking arterial blood sample through the injector
taking blood samples from patients applied with different oxygen concentrations
Sponsors
Zonguldak Bulent Ecevit University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* patients aged between 18-60 years, * ASA I-II risk class with a minimum operative time of 1.5 hour(s) for whom septoplasty operation under elective conditions
Exclusion criteria
* metabolic, endocrine, hepatic, cardiac, or renal diseases, * malignancies and who used a drug with antioxidant properties such as vitamin E-C * acetylcysteine in the last 48 hours, * patients requiring intraoperative 100% O2 inhalation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EFFECTS OF INTRAOPERATIVE OXYGEN USED AT DIFFERENT CONCENTRATIONS ON OXIDATIVE STRESS MARKERS | end of the surgery | TAS and TOS values occurring at different oxygen concentrations |
Countries
Turkey (Türkiye)
Outcome results
None listed